ArticleJournal of the American Heart Association2026
Association Between High-Density Lipoprotein-to-Low-Density Lipoprotein Ratio and Clinical Outcomes in Intracerebral Hemorrhage: Results From a Multicenter Prospective Registry.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
backgroundAlthough the clinical significance of lipidemic profiles has been reported in ischemic stroke, fewer studies reported the clinical significance of these lipidemic profiles in intracerebral hemorrhage. This study aimed to investigate the relationship between high-density lipoprotein to low-density lipoprotein ratios and long-term clinical outcomes including functional dependence and mortality.
methodsBased on a multicenter, real-world registry, our study included patients with intracerebral hemorrhage hospitalized within 72 hours from symptoms onset. Divided into quartiles (Q1-Q4), the association between high-density lipoprotein to low-density lipoprotein ratios and poor functional outcomes (modified Rankin Scale scores 3-6) was investigated using multivariable logistic regression models.
resultsThe final study included 869 intracerebral hemorrhage patients, with a median National Institutes of Health Stroke Scale score of 9 (3-16) and median hematoma volume of 13.4 mL (5.7-31). In the fully adjusted logistic model, where the high-density lipoprotein to low-density lipoprotein ratio was analyzed as a continuous variable, a higher ratio was significantly associated with an elevated odds of poor functional outcome at 90 days (adjusted odds ratio (OR), 4.57 [95% CI 1.70-12.29],
conclusionsOur study delineated the association between high-density lipoprotein to low-density lipoprotein ratios and poor functional outcomes in patients with intracerebral hemorrhage.
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