Observational studyJournal of the American Heart Association2026
Preprocedural Left Atrial Strain as a Predictor of Long-Term Outcomes Following Mitral Valve Interventions in Rheumatic Severe Mitral Stenosis.
Observational study in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study explores whether preprocedural left atrial (LA) strain predicts outcomes in individuals with rheumatic, severe mitral stenosis undergoing mitral valve (MV) interventions.
methodsData were from the MASTER (Multicenter Mitral Stenosis with Rheumatic Etiology) registry, including patients with severe mitral stenosis who underwent percutaneous mitral valvuloplasty or MV replacement. Participants with moderate or greater dysfunction of other valves or missing strain data were excluded. The primary outcome was a composite of all-cause mortality and heart failure hospitalization. Decreased LA reservoir strain was defined as <12.2%, determined through receiver operating characteristic analysis.
resultsAmong 609 individuals (mean age 57.4±12.1 years; 73% women), 424 (69.6%) had MV replacement and 185 (30.4%) underwent percutaneous MV. Those with decreased LA strain (n=307) were older, had more atrial fibrillation, smaller MV area, elevated mean diastolic pressure gradient, and increased right ventricular systolic pressure than those with preserved LA strain (n=302). Over a median follow-up of 6.1 (2.3-10.7) years after MV intervention, 7.7% (n=47) experienced the primary outcome, with significantly higher rates observed in individuals with decreased LA strain (
conclusionsPreprocedural decreased LA reservoir strain was associated with adverse clinical outcomes after MV intervention in individuals with severe mitral stenosis. These findings suggest that LA strain could serve as a marker for optimizing the timing of MV intervention.
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