ArticleJournal of the American Heart Association2026
Cerebral Microbleeds and Long-Term Affective Symptoms in Survivors of Spontaneous Intracerebral Hemorrhage.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
backgroundSpontaneous intracerebral hemorrhage (ICH) is strongly associated with the development of long-term cognitive impairment and neuropsychiatric symptoms (NPS), particularly affective disturbances including depression and anxiety. Although small vessel disease (SVD) underlies most cases of ICH, the contribution of SVD to persistent affective symptoms and the effects of cognitive dysfunction on NPS remain unclear.
methodsWe prospectively recruited 95 survivors of spontaneous ICH (median, 5.7 years post-ICH) between 2021 and 2025 from stroke clinics using standardized clinical protocols. NPS were assessed using the Neuropsychiatric Inventory Questionnaire. Cognitive status was evaluated; brain magnetic resonance imaging was performed to quantify SVD markers. Logistic regression and mediation analyses were used to examine the associations between SVD burden, affective symptoms, and cognition.
resultsAffective symptoms were the most prevalent NPS subsyndrome (37.9%), followed by apathy/vegetative symptoms (32.6%). Patients with affective symptoms showed greater cognitive impairment and higher hypertensive SVD burden, including higher numbers of deep cerebral microbleeds (4.0±5.9 versus 1.2±1.9,
conclusionsAffective symptoms are common long-term outcomes after ICH; deep perforator arteriopathy, especially with the form of deep cerebral microbleeds, contribute to these symptoms; cognitive dysfunction only partly mediates this association. There is a need to screen NPS and evaluate microvascular pathology to assess emotional health post ICH.
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