ArticleJournal of the American Heart Association2026
Location-Specific Analysis of Hematoma Expansion in Intracerebral Hemorrhage.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Risk and Timing of Intracerebral Hemorrhage Expansion Among Patients Treated with Antithrombotic Agents.Neurocritical care · 2026Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHematoma expansion (HE) is a potential modifier of intracerebral hemorrhage (ICH) outcome, yet reducing HE does not necessarily improve prognosis. This may reflect the complex relationship between location, baseline volume, HE, and outcomes, where different locations have varying hematoma growth and differing impacts on prognosis. Prior HE studies have oversimplified location categorization into lobar and deep. Therefore, we aim to investigate how HE varies across more specific location categorization and examine their interactions.
methodsWe retrospectively analyzed 691 nonanticoagulated patients with spontaneous ICH from the University of Hong Kong ICH registry (2011-2022) and 3 regional hospitals (2020-2022). Locations were categorized into lobar, putamen/external capsule, globus pallidus/internal capsule, thalamus, cerebellum, and brainstem. HE was defined as a >33% or >6 mL increase in intraparenchymal hematoma. The associations between location and volume with HE were assessed using multivariable logistic regression. Location-specific volume cutoffs were defined with the receiver operating characteristic curves.
resultsThe HE rates and absolute volume growth differed significantly by location (both
conclusionsThe risk of HE and its association with baseline volume varied by ICH locations. These findings provide novel insight to guide patient selection for antiexpansion therapies.
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