Evidence map›Paper›PMID 41532527›Full record

ArticleJournal of the American Heart Association2026

Sex Differences in Spontaneous Coronary Artery Dissection: A Report of the iSCAD Registry.

Lori M Tam, Sahar Naderi, Gerald Chi, Heather L Gornik, Bryan J Wells, Daniella Kadian-Dodov, Anna Grodzinsky, Angela M Taylor, Connie N Hess, Jennifer Lewey and 16 more

Abstract readMulticenter StudyComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Lori M TamProvidence Heart Institute Portland OR.ORCID 0009-0002-4418-3956
Sahar NaderiDepartment of Cardiology Kaiser Permanente Northern California San Francisco CA.ORCID 0000-0002-2238-184X
Gerald ChiPERFUSE Study Group, Division of Cardiovascular Medicine Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA.ORCID 0000-0002-8371-1689
Heather L GornikDivision of Cardiovascular Medicine and Harrington Heart & Vascular Institute University Hospitals Cleveland OH.ORCID 0000-0002-5849-4010
Bryan J WellsDepartment of Medicine, Division of Cardiology Emory University School of Medicine Atlanta GA.ORCID 0000-0001-9994-7947
Daniella Kadian-DodovThe Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York NY.ORCID 0000-0002-6748-7728
Anna GrodzinskyDepartment of Cardiovascular Diseases, Saint Luke's Mid America Heart Institute University of Missouri-Kansas City Kansas City MO.
Angela M TaylorDivision of Cardiovascular Medicine University of Virginia Medical Center Charlottesville VA.
Connie N HessDivision of Cardiology University of Colorado School of Medicine Aurora CO.ORCID 0000-0002-5830-0511
Jennifer LeweyDivision of Cardiology University of Pennsylvania Perelman School of Medicine Philadelphia PA.ORCID 0000-0003-3483-5527
Stanislav HenkinHeart and Vascular Center Dartmouth-Hitchcock Medical Center Lebanon NH.ORCID 0000-0001-5968-1216
James L OrfordIntermountain Medical Center Intermountain Heart Institute Salt Lake City UT.
Kathryn J LindleyDivision of Cardiovascular Medicine, Department of Medicine Vanderbilt University Medical Center Nashville TN.ORCID 0000-0002-8504-0006
Gretchen L WellsGill Heart and Vascular Institute University of Kentucky School of Medicine Lexington KY.ORCID 0000-0001-6327-156X
Rina MauricioDivision of Cardiology University of Texas Southwestern Medical Center Dallas TX.ORCID 0000-0002-3556-9913
Michelle L OuelletteCatholic Medical Center New England Heart and Vascular Institute Manchester NH.
Jeffrey TrostDivision of Cardiology Johns Hopkins University School of Medicine Baltimore MD.
Agnes KoczoUniversity of Pittsburgh Medical Center Pittsburgh PA.ORCID 0000-0002-8867-0169
Stephanie SaucierHartford Healthcare Hartford CT.ORCID 0009-0000-2525-5657
Daniela R CrousillatDivision of Cardiovascular Sciences, Department of Medicine and Obstetrics and Gynecology University of South Florida Morsani College of Medicine Tampa FL.
Sonia TolaniDivision of Cardiology Columbia University Irving Medical Center/New York-Presbyterian Hospital New York NY.ORCID 0000-0002-6004-1205
Jason C KovacicThe Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai New York NY.ORCID 0000-0003-4555-769X
C Michael GibsonPERFUSE Study Group, Division of Cardiovascular Medicine Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA.ORCID 0000-0002-4857-9125
Katherine K LeonSCAD Alliance Alexandria VA.ORCID 0009-0000-4714-064X
Malissa J WoodLee Health Heart Institute Fort Myers FL.ORCID 0000-0003-0482-1116
Esther S H KimDivision of Cardiovascular Medicine Vanderbilt University Medical Center Nashville TN.ORCID 0000-0002-3386-6359

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpontaneous coronary artery dissection is a cause of myocardial infarction, which predominantly affects middle-aged women. There are limited data on men with spontaneous coronary artery dissection.

methodsInformation on demographics, presenting characteristics, in-hospital outcomes including major adverse cardiovascular events (composite of myocardial infarction, cerebrovascular accident, or heart failure), length of stay, and discharge medications in men and women were obtained from the multicenter iSCAD (International Spontaneous Coronary Artery Dissection) registry.

resultsOf 1252 patients enrolled from 2019 to 2023, 80 (6.4%) were men. Mean age did not significantly differ between sexes (men, 50.2±10.3 versus women 49.7±10.4;

conclusionsIn a large spontaneous coronary artery dissection registry, there were significant sex differences in presentation, baseline medical conditions, and triggers. In-hospital outcomes were similar, but length of stay was longer for women. Men were more often discharged on statins and dual antiplatelet therapy.

Indexed as

Coronary Vessel AnomaliesVascular DiseasesAdultFemaleHumansLength of StayMaleMiddle AgedRegistriesRisk FactorsSex Factorsangina pectorisfibromuscular dysplasiamyocardial infarctionsex differencesspontaneous coronary artery dissection

Identifiers

PMID41532527
PMCPMC12919466

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.