Evidence map›Paper›PMID 41532446›Full record

Trial reportJournal of clinical pharmacology2026

No QTcF Prolongation with Sepiapterin: Results From a Thorough QT Study in Healthy Subjects at Therapeutic and Supratherapeutic Doses.

Lan Gao, Hongqi Xue, Borje Darpo, Kimberly Ingalls, Diksha Kaushik, Neil Smith, Ronald Kong, Lee Golden

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lan GaoPTC Therapeutics, Inc., Warren, NJ, USA.ORCID https://orcid.org/0000-0002-2528-7656
Hongqi XueClario, Philadelphia, PA, USA.
Borje DarpoClario, Philadelphia, PA, USA.
Kimberly IngallsPTC Therapeutics, Inc., Warren, NJ, USA.
Diksha KaushikPTC Therapeutics, Inc., Warren, NJ, USA.
Neil SmithPTC Therapeutics, Inc., Warren, NJ, USA.ORCID https://orcid.org/0000-0001-8876-3958
Ronald KongPTC Therapeutics, Inc., Warren, NJ, USA.ORCID https://orcid.org/0000-0002-4692-7499
Lee GoldenPTC Therapeutics, Inc., Warren, NJ, USA.

Funding

PTC Therapeutics, Inc
6 · The paper itself

Abstract

Sepiapterin and its major metabolite 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH

Indexed as

Long QT SyndromePterinsAdultBiopterinsCross-Over StudiesDose-Response Relationship, DrugDouble-Blind MethodElectrocardiographyFemaleHealthy VolunteersHeart RateHumansMaleMiddle AgedMoxifloxacinYoung AdultBiopterinsMoxifloxacinPterinssapropterinsepiapterin6R‐L‐erythro‐5,6,7,8‐tetrahydrobiopterinconcentration‐QT analysisphenylketonuriaQT prolongationsepiapterinthorough QT study

Identifiers

PMID41532446
PMCPMC12801174

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.