ArticleInternational journal of surgery (London, England)2026
Efficacy and cost-effectiveness of extending risk-stratified colorectal cancer screening: evidence from China's first province-wide program.
Article in International journal of surgery (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Age Inflection Points of Colorectal Adenoma Risk in Young Adults: A Joinpoint Regression Analysis of a Single-Center Retrospective Colonoscopy-Based Cohort.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChina accounts for nearly 30% of global colorectal cancer (CRC) cases but has only 3% screening coverage, underscoring the urgent need to expand coverage. We evaluated the efficacy and cost-effectiveness of extending risk-stratified CRC screening based on the first province-wide, full-coverage initiative in China (2020-2024).
methodsThis population-based study covered 17 780 462 average-risk residents aged 50-74. Those participants were stratified using the Revised Asia-Pacific Colorectal Screening Score (APCS) and fecal immunochemical testing (FIT). High-risk participants (APCS ≥5 or FIT-positive) were referred for colonoscopy. A health care system perspective Markov model simulated a cohort of 100 000 individuals to compare screening strategies by initiation age and frequency. Outcomes included screening yield (participation, detection, and death averted), resource utilization (colonoscopies, costs per lesion detected, and number needed to screen), and cost-effectiveness. Incremental cost-effectiveness ratios (ICERs), benchmarked against three times per capita GDP (USD $ 53 235 in 2023) per quality-adjusted life-year (QALY) gained. Sensitivity analyses were performed.
resultsAmong 10 364 955 eligible participants, 1 582 606 (15.27%) were high-risk, with 38.92% colonoscopy compliance. Screening detected 59 954 advanced adenomas (AAs) and 5708 CRCs, with 11 and 108 colonoscopies needed per lesion, respectively. The cost per AA and CRC detected was $ 1588 and $ 16 684. All screening strategies were cost-effective regardless of the starting age or frequency, yielding ICERs of $ 6718- $ 21 177 per QALY. Annual screening starting at 40-44 years achieved optimal effectiveness (19 955 QALYs gained, 1126 CRC deaths averted per 100 000).
conclusionThis first province-wide, full-coverage screening initiative demonstrates the effectiveness and cost-effectiveness of extending risk-based CRC screening in resource-rich regions of China, supporting expanded coverage and informing policy decisions for CRC prevention in similar settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.