ArticleMovement disorders : official journal of the Movement Disorder Society2026
Early Autonomic Burden in Prodromal Parkinson's Disease Predicts Cognitive Impairment.
Article in Movement disorders : official journal of the Movement Disorder Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Aluminium neurotoxicity beyond the brain: a mechanistic systematic review of autonomic and peripheral dysfunction.Frontiers in physiology · 2026Pooled it
- Baseline peripheral inflammatory profiles predict phenoconversion in prodromal Parkinson's disease: a longitudinal cohort study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Brain-first and body-first subtypes of Lewy body disease.Nature reviews. Neurology · 2026Review
- Running out the clock: Circadian rhythm dysfunction in cognitive disease.International review of neurobiology · 2026Review
- Evaluation of orthostatic dizziness and lightheadedness in older adults: symptoms not to be taken lightly.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutonomic dysfunction is a known contributor to cognitive impairment in Parkinson's disease (PD), but its impact during prodromal stage is unknown.
objectiveThe aim was to determine whether early autonomic burden predicts incident cognitive impairment in prodromal PD.
methodsWe analyzed data from Parkinson's Progression Markers Initiative participants. Autonomic dysfunction was defined as Scales for Outcomes in Parkinson's Disease Autonomic Dysfunction score ≥13, documented prior to phenoconversion. Cox regression assessed the predictors of cognitive impairment, and mixed-effects analysis of variance compared domain-specific cognitive trajectories.
resultsData on 382 participants were analyzed. Early autonomic dysfunction was significantly associated with increased risk of mild cognitive impairment or dementia (P < 0.001), especially in semantic fluency and letter-number sequencing. Cardiovascular autonomic burden, specifically, was a strong independent predictor (HR = 5.21, P = 0.01).
conclusionsAutonomic dysfunction in prodromal PD is a risk factor for cognitive decline, providing opportunity for early risk stratification and intervention. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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