Evidence map›Paper›PMID 41532115›Full record

ArticleBiomedical optics express2026

Voltage imaging with periodic structured illumination.

Forest Speed, Alec Teel, Timothy Young, Larry V Baker, Gregory L Futia, Diego Restrepo, Emily A Gibson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Forest SpeedDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Alec TeelDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Timothy YoungDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Larry V BakerDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Gregory L FutiaDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID https://orcid.org/0000-0003-2266-9525
Diego RestrepoDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Emily A GibsonDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID https://orcid.org/0000-0002-3436-1483

Funding

Development of 3D-FAST Optical Interface for Rapid Volumetric Neural Sensing and ModulationR01NS123665 · NINDS · UNIVERSITY OF COLORADO DENVER · PI GIBSON, EMILY, WELLE, CRISTIN G · 2021 to 2021
$2.7M
NINDS NIH HHS R01 NS123665
6 · The paper itself

Abstract

We utilize periodic structured illumination with pseudo-HiLo (pHiLo) image reconstruction for in vivo voltage imaging. We demonstrate reduced signal from out-of-focus cells, which contaminates voltage activity for in-focus cells of interest, with pHiLo compared to traditional widefield recordings taken with uniform illumination and pseudo-widefield (pWF) reconstructions. We compare spike peak-to-noise ratio (PNR) and cell-background correlation for time courses extracted using pHiLo and soma-targeted widefield illumination (TI). We discuss tradeoffs between out-of-focus light reduction, signal-to-noise ratio, and temporal resolution for pHiLo in the context of high-speed voltage imaging in awake mice.

Identifiers

PMID41532115
PMCPMC12795438

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.