Evidence map›Paper›PMID 41532044›Full record

ArticleJournal of medicine and life2025

Surgical excision of cerebral glioma and multimodal treatment including Cerebrolysin: a case report.

Jose Daniel Salvador Ruiz González, Andrea Tapia

Abstract readCase Reports
In one paragraph

Article in Journal of medicine and life, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jose Daniel Salvador Ruiz GonzálezDepartment of Neurosurgery, Fundación Clínica Médica Sur, Ciudad de Mexico, Mexico.
Andrea TapiaInstituto Mexicano del Seguro Social , Hospital General Zona 1, Cuernavaca Morelos, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multimodal treatment of patients with a brain tumor primarily involves microsurgical excision, ideally radical, or at least subtotal resection. Tumors in deep or inaccessible locations may require biopsy followed by adjuvant therapy with chemotherapy, radiotherapy, or radiosurgery. Beyond controlling tumor growth, preserving neurological function and promoting brain plasticity are essential goals. Persistent inflammation and intracranial hypertension can trigger secondary injury through edema, excitotoxicity, and ischemia, potentially resulting in irreversible neuronal damage. Multimodal strategies, including neuroprotective measures such as Cerebrolysin administration, may help prevent or mitigate these secondary processes, supporting recovery and functional outcomes. Clinically, patients may present with headache, nausea, vomiting, seizures, or subtle cognitive and motor deficits, progressing in severe cases to deterioration of consciousness. Incorporating cerebroprotective interventions in perioperative management represents a promising approach to enhance recovery, functional independence, and quality of life in neurosurgical oncology patients.

Indexed as

Amino AcidsBrain NeoplasmsGliomaCombined Modality TherapyHumansMaleAmino Acidscerebrolysinbrain protectioncerebral gliomaCerebrolysinmultimodal neurooncological treatment

Identifiers

PMID41532044
PMCPMC12794102

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.