Beta-3 Adrenoreceptor Agonist Mirabegron Improves Right Ventricular Function in a Rat Monocrotaline-Induced Pulmonary Hypertension Model.
Pedro Mendes-Ferreira, Birger Tielemans, Allard Wagenaar, Caroline Bouzin, Rui Adão, Peter Pokreisz, Delphine De Mulder, Adelino Leite-Moreira, Carmen Brás-Silva, Jean-Luc Balligand and 4 more
Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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5 · Who and what money
Authors and funding
14 authors.
Pedro Mendes-FerreiraLaboratory of Respiratory Diseases & Thoracic Surgery (BREATHE), Department of Chronic Diseases & Metabolism (CHROMETA) KU Leuven - University of Leuven Leuven Belgium.
Birger TielemansLaboratory of Respiratory Diseases & Thoracic Surgery (BREATHE), Department of Chronic Diseases & Metabolism (CHROMETA) KU Leuven - University of Leuven Leuven Belgium.ORCID https://orcid.org/0000-0002-1775-1797
Allard WagenaarLaboratory of Respiratory Diseases & Thoracic Surgery (BREATHE), Department of Chronic Diseases & Metabolism (CHROMETA) KU Leuven - University of Leuven Leuven Belgium.
Caroline BouzinIREC Imaging Platform (2IP, RRID: SCR_023378), Institute of Experimental and Clinical Research (IREC) Université catholique de Louvain (UCLouvain) Brussels Belgium.
Rui AdãoRISE-Health, Department of Surgery and Physiology Faculty of Medicine of the University of Porto Porto Portugal.
Peter PokreiszDepartment of Cardiovascular Sciences KU Leuven - University of Leuven, Campus Gasthuisberg Leuven Belgium.
Delphine De MulderPole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC) Université catholique de Louvain (UCLouvain) Brussels Belgium.
Adelino Leite-MoreiraRISE-Health, Department of Surgery and Physiology Faculty of Medicine of the University of Porto Porto Portugal.
Carmen Brás-SilvaRISE-Health, Department of Surgery and Physiology Faculty of Medicine of the University of Porto Porto Portugal.
Jean-Luc BalligandPole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC), and Cliniques Universitaires Saint-Luc Université catholique de Louvain (UCLouvain) Brussels Belgium.
Chantal DessyPole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC) Université catholique de Louvain (UCLouvain) Brussels Belgium.
Marion DelcroixLaboratory of Respiratory Diseases & Thoracic Surgery (BREATHE), Department of Chronic Diseases & Metabolism (CHROMETA), Clinical Department of Respiratory Diseases University Hospitals KU Leuven - University of Leuven Leuven Belgium.ORCID https://orcid.org/0000-0001-8394-9809
Rozenn QuarckLaboratory of Respiratory Diseases & Thoracic Surgery (BREATHE), Department of Chronic Diseases & Metabolism (CHROMETA), Clinical Department of Respiratory Diseases University Hospitals KU Leuven - University of Leuven Leuven Belgium.ORCID https://orcid.org/0000-0002-8293-6261
Catharina BelgeLaboratory of Respiratory Diseases & Thoracic Surgery (BREATHE), Department of Chronic Diseases & Metabolism (CHROMETA), Clinical Department of Respiratory Diseases University Hospitals KU Leuven - University of Leuven Leuven Belgium.ORCID https://orcid.org/0000-0002-8263-6058
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Considering the beta-3 adrenoceptor agonist, mirabegron, may display vasodilator and cardioprotective properties, we investigated the therapeutic potential of mirabegron in monocrotaline-induced pulmonary hypertension in rats. High-dose mirabegron improved right ventricular function, and endothelium-dependent relaxation in isolated rat pulmonary arteries, suggesting that mirabegron may be beneficial in pulmonary arterial hypertension.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Beta-3 Adrenoreceptor Agonist Mirabegron Improves Right Ventricular Function in a Rat Monocrotaline-Induced Pulmonary Hypertension Model. · full record | OpenQuestion