Evidence map›Paper›PMID 41532036›Full record

ArticlePulmonary circulation2026

Cerebral Tissue Pulmonary Embolism Masquerading as Primary Graft Dysfunction After Lung Transplantation.

Shimon Izhakian, Moshe Heching, Ludmila Fridel, Dror Rosengarten, Mordechai R Kramer, Osnat Shtraichman

Abstract read
In one paragraph

Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shimon IzhakianPulmonary Institute Beilinson Hospital, Rabin Medical Center Petah Tikva Israel.ORCID https://orcid.org/0000-0003-1150-1057
Moshe HechingPulmonary Institute Beilinson Hospital, Rabin Medical Center Petah Tikva Israel.
Ludmila FridelFaculty of Medicine Tel Aviv University Tel Aviv Israel.
Dror RosengartenFaculty of Medicine Tel Aviv University Tel Aviv Israel.
Mordechai R KramerPulmonary Institute Beilinson Hospital, Rabin Medical Center Petah Tikva Israel.
Osnat ShtraichmanPulmonary Institute Beilinson Hospital, Rabin Medical Center Petah Tikva Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early graft dysfunction following lung transplantation is commonly attributed to primary graft dysfunction (PGD). However, other rare etiologies may present with similar clinical and radiologic features. We report a unique case of a 58-year-old male with idiopathic pulmonary fibrosis who underwent bilateral lung transplantation. The donor was a young adult with traumatic brain injury. Within hours post-transplant, the recipient developed severe hypoxemia and diffuse infiltrates on chest imaging, consistent with Grade 3 PGD. Despite supportive therapy, there was limited improvement. Histopathological examination of transbronchial biopsies revealed cerebral cortical neurons and glial tissue embedded in the pulmonary vasculature, confirming cerebral tissue embolism. This case highlights cerebral tissue pulmonary embolism as an under-recognized cause of early allograft dysfunction. Clinicians should consider donor-derived embolic events, particularly in trauma-related donors, in the differential diagnosis of PGD-like presentations.

Indexed as

brain tissue embolilung transplantationprimary graft dysfunction

Identifiers

PMID41532036
PMCPMC12794536

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.