Evidence map›Paper›PMID 41532020›Full record

ArticleFrontiers in chemistry2025

Regioselective synthesis of novel spiro-isoxazolines congeners as antimicrobial agents:

Rachid Bouzammit, Soumia Ait Assou, Mohammed Er-Rajy, Noura Aflak, Lahoucine Bahsis, Mohammed Chalkha, Mohammed El Hassouni, Mohammed Lachkar, Taibi Ben Hadda, Daryn Benson and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rachid BouzammitEngineering Laboratory of Organometallic, Molecular Materials and Environment (LIMOME), Faculty of Sciences, University Sidi Mohamed Ben Abdellah, Fez, Morocco.
Soumia Ait AssouBiotechnology, Environment, Agri-Food and Health Laboratory, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Mohammed Er-RajyLIMAS Laboratory, Chemistry Department, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Noura AflakTeam of Organic Chemistry and Valorization of Natural Substances, Faculty of Sciences, University Ibn Zohr, Agadir, Morocco.
Lahoucine BahsisLaboratory of Analytical and Molecular Chemistry/LCAM, Polydisciplinary Faculty of Safi, University Cadi Ayyad, Safi, Morocco.
Mohammed ChalkhaEngineering Laboratory of Organometallic, Molecular Materials and Environment (LIMOME), Faculty of Sciences, University Sidi Mohamed Ben Abdellah, Fez, Morocco.
Mohammed El HassouniBiotechnology, Environment, Agri-Food and Health Laboratory, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Mohammed LachkarEngineering Laboratory of Organometallic, Molecular Materials and Environment (LIMOME), Faculty of Sciences, University Sidi Mohamed Ben Abdellah, Fez, Morocco.
Taibi Ben HaddaEuro-Medeterranean University of Fes (UEMF), Fez, Morocco.
Daryn BensonEuro-Medeterranean University of Fes (UEMF), Fez, Morocco.
Abdullah A AlyousefClinical Laboratory Sciences Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Mourad A M Aboul-SoudCenter of Excellence in Biotechnology Research (CEBR), College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
John P GiesyDepartment of Veterinary Biomedical Sciences and Toxicology Centre, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Ghali Al HouariEngineering Laboratory of Organometallic, Molecular Materials and Environment (LIMOME), Faculty of Sciences, University Sidi Mohamed Ben Abdellah, Fez, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: A new class of spiroisoxazolines was efficiently synthesized through a regioselective cycloaddition between arylidene tetralone Methods: The structures and regioselectivity of the obtained cycloadducts were confirmed by 1H, 13C-NMR, IR, elemental analysis, and mass spectrometry, and further supported by theoretical calculations that explained the reaction process and the regioselective results. The antimicrobial profile of the synthetized spiro derivatives was evaluated against the yeast Candida albicans, the Gram-postive bacteria ( Results and Discussion: Two spiroisoxazolines, defined as

Indexed as

1,3-dipolar cycloadditionantimicrobial activityin silico studiesPetra/Osiris/Molinspiration analysesreactions with azo Schiff basesregioselectivityspiroisoxazoline

Identifiers

PMID41532020
PMCPMC12791170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.