Evidence map›Paper›PMID 41531948›Full record

ArticleACS medicinal chemistry letters2026

A Novel Class of Orally Bioavailable Phenylglycine-Benzoxaborole Conjugates with Antimalarial Activity and Potentially Novel Mechanism of Action.

Mokhitli Morake, Dale Taylor, Dina Coertzen, Mathew Njoroge, Liezl Krugmann, Meta Leshabane, Shanté da Rocha, Tarrick Qahash, Gareth Girling, Rachael Coyle and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mokhitli MorakeDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.ORCID https://orcid.org/0000-0001-5596-3160
Dale TaylorDrug Discovery and Development Centre (H3D), Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Observatory, 7925, South Africa.
Dina CoertzenDepartment of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028 Pretoria, South Africa.
Mathew NjorogeDrug Discovery and Development Centre (H3D), Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Observatory, 7925, South Africa.
Liezl KrugmannDrug Discovery and Development Centre (H3D), Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Observatory, 7925, South Africa.
Meta LeshabaneDepartment of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028 Pretoria, South Africa.
Shanté da RochaDepartment of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028 Pretoria, South Africa.
Tarrick QahashDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, State College, Pennsylvania 16802, United States of America.
Gareth GirlingWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, United Kingdom.
Rachael CoyleWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, United Kingdom.
Marcus C S LeeWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, United Kingdom.
Sergio WittlinSwiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland.ORCID https://orcid.org/0000-0002-0811-0912
Manuel LlinásDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, State College, Pennsylvania 16802, United States of America.
Lyn-Marie BirkholtzDepartment of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028 Pretoria, South Africa.ORCID https://orcid.org/0000-0001-5888-2905
Gregory S BasarabDrug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.ORCID https://orcid.org/0000-0001-5684-6046
Kelly ChibaleDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.ORCID https://orcid.org/0000-0002-1327-4727

Funding

Wellcome Trust
6 · The paper itself

Abstract

A new class of benzoxaboroles with a phenylglycine appendage was found to display

Indexed as

BenzoxaborolesCPSF3microsomal stabilitystructure−activity relationship

Identifiers

PMID41531948
PMCPMC12794096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.