ArticlePsoriasis (Auckland, N.Z.)2026
Bidirectional Associations Between Substance Abuse and Psoriasis: A Prospective Cohort Study.
Article in Psoriasis (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: Psoriasis and substance abuse remains a serious healthcare burden. However, associations between substance abuse and psoriasis have not been elucidated. Objective: To evaluate the bidirectional associations between substance abuse and psoriasis. Methods and Subjects: Based on the UK Biobank data, we conducted two prospective cohort studies to compare the risk of incident psoriasis in participants with versus without substance abuse (Cohort 1) and the risk of incident substance abuse in participants with versus without psoriasis (Cohort 2). Incident substance abuse (ICD: F10-F19) and psoriasis (ICD: L40) were primarily determined from hospital and primary care data, death registries and self-assessments. Results: In Cohort 1, 4,097 of 454,245 developed psoriasis during follow-up. Baseline substance abuse was linked to an increased psoriasis risk (hazard ratio [HR]: 2.31, P<0.001), notably in alcohol and tobacco users (HRs: 2.29 and 2.33, Conclusion: Our findings identify bidirectional positive associations of substance abuse with psoriasis. This association is especially pronounced in those with both high genetic risk and alcohol or tobacco abuse. It is suggested that clinicians should consider alcohol or tobacco abuse among psoriasis patients to improve their life quality.
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