ArticleJournal of aging research2026
Relationship Between Salivary Metabolites and Skeletal Muscle Index in Older Male Patients: A Retrospective Observational Pilot Study to Identify Potential Biomarkers.
Article in Journal of aging research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Relationship Between Salivary Metabolites and Skeletal Muscle Index in Older Male Patients: A Retrospective Observational Pilot Study to Identify Potential Biomarkers.Journal of aging research · 2026Article
- Salivary Metabolomics: A Pilot Study for Screening Biomarkers in Mild-to-moderate Periodontitis.In vivo (Athens, Greece)Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Nutritional assessment during the perioperative period is critical, particularly for older patients at high risk for complications. Bioelectrical impedance analysis (e.g., InBody) is commonly used to assess skeletal muscle mass via the skeletal muscle index (SMI). However, its use is limited in patients with contraindications, including implantable cardiac devices. Objective: Therefore, this study explored a noninvasive alternative: assessing the relationship between salivary metabolites and SMI to identify potential biomarkers associated with muscle mass. Methods: This retrospective study analyzed data from male preoperative patients who had both InBody analysis and salivary metabolomics data collected between January 2021 and March 2024. Salivary metabolites, including butyrate and hexanoate, were quantified using capillary electrophoresis time-of-flight mass spectrometry (CE-TOF MS). Body composition parameters, including SMI, and blood nutritional indicators, were obtained. Volcano plot analysis identified metabolites significantly differing between patients with SMI ≥ 7.0 and < 7.0 kg/m Results: Patients with low SMI were significantly older than those with high SMI. While body composition indices differed significantly, general nutritional blood markers remained comparable. Volcano plot analysis showed significantly higher salivary butyrate and hexanoate levels in patients with SMI ≥ 7.0 kg/m Conclusions: This exploratory study suggests that salivary metabolites, particularly butyrate and hexanoate, along with age, may serve as potential indicators for discriminating SMI status. These findings suggest the potential utility of salivary metabolites as noninvasive biomarkers for assessing muscle mass in the perioperative setting. This could enable early sarcopenia detection and enhanced nutritional management in older patients, particularly those with contraindications.
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