ReviewBrain circulation
A literature review on neuron scaffolding for repairing peripheral nerves: Advances, challenges, and future directions.
Review in Brain circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Natural Polymers in Tissue Engineering and Regeneration: Material-Cell Mechanotransduction, Biofabrication Strategies, and Clinical Translation.Biomedicines · 2026Review
- Stem cell-derived secretome and dental pulp stem cells enhance sciatic nerve regeneration in a rat sciatic neurotmesis model using chitosan nerve conduits.Frontiers in cell and developmental biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral nerve injuries (PNIs) present significant clinical challenges and affect a substantial portion of the population. Current treatments often fall short of desirable outcomes, leading to a diminished quality of life for patients. Advancements in neuron scaffolding materials offer promising solutions to enhance the clinical management of PNIs and address the limitations of traditional treatments. This paper assesses the current state of treatments, examines the anatomy and physiology of peripheral nerves, and discusses the mechanisms of PNIs and their impact on recovery. It also explores the principles of neuron scaffolding and recent advancements in various natural and synthetic biomaterials. This review focuses on collagen, fibrin, chitosan, poly (lactic acid), poly (glycolic acid), and polycaprolactone (PCL), detailing each material's advantages and challenges in neuron scaffolding applications. This review paper focuses on the innovative use of neuron scaffolding in the treatment of PNIs, emphasizing the potential of both natural and synthetic biomaterials to enhance nerve regeneration. The study underlines the promising future of neuron scaffolding while acknowledging the current limitations that need to be addressed for more effective treatment outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.