Evidence map›Paper›PMID 41531833›Full record

ArticleTransplantation direct2026

Association of Carboxypeptidase B2 Gene Polymorphisms With Graft Loss in Kidney Transplantation.

Felix Poppelaars, Siawosh K Eskandari, Jeffrey Damman, Ashley Frazer-Abel, V Michael Holers, Bradley P Dixon, Mohamed R Daha, Jan-Stephan F Sanders, Marc A Seelen, Bernardo Faria and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Felix PoppelaarsDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-5173-8078
Siawosh K EskandariDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-4867-4170
Jeffrey DammanDepartment of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0001-5997-7551
Ashley Frazer-AbelExsera BioLabs, University of Colorado School of Medicine, Aurora, CO.
V Michael HolersDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO.ORCID https://orcid.org/0000-0002-5634-7746
Bradley P DixonDepartments of Pediatrics and Medicine, University of Colorado School of Medicine, Aurora, CO.ORCID https://orcid.org/0000-0003-2173-3695
Mohamed R DahaDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-0113-0750
Jan-Stephan F SandersDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0001-9112-5148
Marc A SeelenDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0003-2240-4682
Bernardo FariaDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0001-9112-8920
Mariana Gaya da CostaDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-9201-5108
Joshua M ThurmanDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO.ORCID https://orcid.org/0000-0002-3476-9956

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Plasma carboxypeptidase B2 (CPB2) is an enzyme that regulates protein activities by cleaving C-terminal amino acids. With its anti-inflammatory and antifibrinolytic properties, CPB2 can have protective or harmful effects on disease. We investigated the impact of CPB2 on long-term outcomes after kidney transplantation. Methods: This observational cohort study involved 1271 renal transplant pairs from the University Medical Center Groningen in The Netherlands and analyzed 4 CPB2 gene ( Results: The CPB2 rs3742264 polymorphism in the donor was associated with a reduced risk of graft loss after kidney transplantation (hazard ratio: 0.71 for the Conclusions: Kidney allografts possessing the

Identifiers

PMID41531833
PMCPMC12794963

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.