ReviewiScience2026
The arginase-polyamine signaling axis in immune cells: Implications for immune modulation and host-pathogen interactions.
Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Metabolite sensing receptors in macrophage reprogramming: from inflammation to resolution.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- The Diet-Microbiota-Polyamine Axis in Intestinal Aging: Microbial Pathways, Functional Foods, and Physiological Implications.Nutrients · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immune system employs complex metabolic pathways to regulate host-pathogen interactions. Among these, the arginase-polyamine axis is a crucial modulator of both innate and adaptive immunity. Despite significant progress, the precise roles and regulatory mechanisms governing the arginase-polyamine axis in immune cell function remain incompletely understood. This review aims to provide a comprehensive analysis of the arginase-polyamine axis, highlighting its role in maintaining immune homeostasis and preserving the functional integrity of various immune cell types. Furthermore, we discuss the strategies used by diverse pathogens to manipulate this pathway, facilitating the creation of immunosuppressive microenvironments that promote their intracellular survival and replication in the host. Finally, we highlight the potential of innovative therapeutic strategies that target arginase-polyamine signaling pathways, which can effectively modulate immune responses in the context of infectious diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.