ArticleiScience2026
Chronic hepatitis b coinfection and survival in pediatric T-ALL: A propensity-matched analysis.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
In this retrospective study of 251 pediatric patients with T cell acute lymphoblastic leukemia (T-ALL), chronic hepatitis B virus (HBV) infection with acute exacerbation (CHB-AE) was associated with significantly poorer outcomes. Compared to patients with HBV-negative, the CHB-AE cohort had markedly inferior 5-year event-free survival (13.24% vs. 80.58%) and overall survival. After using propensity score matching to balance baseline characteristics, the difference in event-free survival remained significant. Subgroup analyses consistently showed worse outcomes for patients with CHB-AE, particularly those with high-risk features such as elevated leukocyte counts or central nervous system involvement. The study identifies HBV coinfection as an independent adverse prognostic factor in pediatric T-ALL. These findings highlight the urgent need for prospective studies to investigate the underlying mechanisms and to develop novel therapeutic strategies for this high-risk patient subgroup.
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