ArticleReports of biochemistry & molecular biology2025
Status of Serum Levels of Oxidative Stress Biochemical Markers and Total Antioxidant Capacity in Primary Hypothyroidism.
Article in Reports of biochemistry & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Primary hypothyroidism (HT) has been demonstrated to be associated with oxidative stress. This study was designed to assess the role of oxidative stress in the pathogenesis of primary hypothyroidism. Methods: The study included 97 subjects, age range (of 29-62 years); 57 of them had been diagnosed with primary hypothyroidism, and 40 healthy subjects as controls in Baghdad, during Oct 2023 to 2024. The primary HT subjects were sub-classified into the newly diagnosed primary HT group (n=24) and the established primary HT (n=33) group. Investigations encompassed serum evaluation of total antioxidant capacity (TAC), total oxidant status (TOS), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), NADPH oxidase-4 (NOX4), and Anti-TPO utilizing enzymatic colorimetric methods and enzyme-linked immunosorbent assay (ELISA). Results: The median and 1 Conclusions: TheElevated levels of serum 8-oxodG, NOX4, and TOS reflect the underlying oxidative damage associated with reduced thyroid function and may participate to the pathogenesis of primary hypothyroidism.
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