ReviewCureus2025
Habitual Coffee Consumption and Systemic Health Outcomes: A Comprehensive Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review analyzes extensive scientific data linking habitual coffee consumption to a wide range of physiological outcomes and divides them into cardiovascular, metabolic, and organ-specific effects. Unlike previous assumptions, moderate coffee intake positively affects many aspects of the health of the adult population. We can observe beneficial effects that translate into patients' longevity as well as reduced risks of chronic diseases. After analyzing the studies, the most significant protective associations were identified in the cardiovascular system, where moderate consumption (three to four cups daily, corresponding to approximately 450-600 mL of coffee) correlates with reduced all-cause and cardiovascular mortality, and a lower risk of heart failure. Many studies have highlighted the chemo-preventive potential of coffee constituents, indicating a reduced risk of specific malignancies, including liver and prostate cancer. The health consequences that manifest themselves clinically also include improved metabolic homeostasis, specifically a lower incidence of type 2 diabetes mellitus and liver fibrosis. This impact also extends to the central nervous system, where there is a clear correlation between caffeine intake and neuroprotection against neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Evidence indicates a "J-shaped" relationship in many cases, suggesting that moderate intake is optimal. Conversely, supraphysiological consumption can induce transient hemodynamic disturbances, and unfiltered preparations may negatively impact lipid profiles due to higher diterpene content. Furthermore, evidence supports a linear dose-response relationship between caffeine intake and adverse pregnancy outcomes, specifically pregnancy loss, highlighting the need for strict caution in prenatal care. Due to the proven bioactive properties of compounds like chlorogenic acid and caffeine, updated public health perspectives are needed to recognize coffee not merely as a stimulant, but as a functional dietary component that promotes a healthy lifestyle, which will translate into the reduced burden of non-communicable diseases in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.