Low-Grade B-cell Lymphoma in Primary Sjögren's Syndrome: A Case Report.

Thanda Aung, Giovanni Botten, Anamaria Munteanu, Bita V Naini, Anthony Pastizzo, Kanwarpal S Kahlon

Abstract readCase Reports

In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thanda AungRheumatology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.

Giovanni BottenPathology and Labratory Medicine, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.

Anamaria MunteanuPathology and Laboratory Medicine, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.

Bita V NainiPathology and Laboratory Medicine, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.

Anthony PastizzoRheumatology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.

Kanwarpal S KahlonHematology and Oncology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary Sjögren's syndrome (pSS) is associated with an increased risk of lymphoproliferative disorders, including non-Hodgkin lymphoma (NHL). We report the vase of a woman with longstanding pSS who presented with progressive weight loss, massive splenomegaly, and cytopenias. Extensive hepatologic evaluation, including transjugular liver biopsy, showed no evidence of cirrhosis or intrinsic liver disease. Bone marrow biopsy established the diagnosis of a low-grade B-cell lymphoma consistent with marginal zone lymphoma. The patient was treated with rituximab monotherapy and demonstrated a good clinical response. This case underscores the importance of maintaining a high index of suspicion for lymphoproliferative disease in pSS patients who develop unexplained splenomegaly and cytopenias, even in the absence of lymphadenopathy or classic B symptoms. When hematologic abnormalities persist despite negative preliminary investigations, bone marrow biopsy remains essential for timely and definitive diagnosis.

Indexed as

cytopeniasmarginal zone lymphomanon-hodgkin lymphomaprimary sjögren's syndromerituximabsplenomegaly

Identifiers

PMID41531558

DOI10.7759/cureus.99140

PMCPMC12795398

What OpenQuestion holds

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