ArticleBioactive materials2026
Mossy-textured hydroxyapatite-modified poly (lactic-co-glycolic acid) microspheres promote collagen regeneration via calcium/TGF-β and chemokine signaling pathways in soft tissue augmentation.
Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Regenerative Functional Microspheres for Aesthetic Medicine: Mechanism, Materials, Fabrication, and Clinical Applications.Advanced healthcare materials · 2026Review
- Optimization of Bioink Formulations and Bioprinting Conditions for Enhanced Cell Viability in Particle-Containing Constructs.Polymers · 2026Article
- Preparation of Uniform PEG-PLLA Microspheres via Membrane Emulsification for Soft Tissue Filling Applications.Journal of functional biomaterials · 2026Article
- The Sr-HA-loaded PLGA cage structure combines cells to construct a bone tissue repair unit.Regenerative biomaterials · 2026Article
- Pitaya‑inspired compartmentalized microspheres with natural tannic acid-copper coating orchestrate smart release of ions and multi-drugs for synergistic treatment of infected bone defects.Regenerative biomaterials · 2026Article
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Authors and funding
13 authors.
Funding
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Abstract
Skin aging resulting from collagen loss induced by endogenous and exogenous stimuli has become an important factor affecting skin aesthetics and quality of life. The use of simple and efficient soft tissue fillers represents an effective approach to promote collagen regeneration and restore soft tissue support. In this study, mossy-textured hydroxyapatite (CaHA)-modified poly (lactic-co-glycolic acid) (PLGA) composite microspheres (CaHA/PLGA) are developed. These microspheres feature a uniform and stable coating of CaHA beads on the surface of PLGA microspheres and possess particle sizes suitable for soft tissue filling (30-60 μm). The CaHA beads impart a highly porous structure, enhanced protein adsorption, and delayed degradation properties to the composite microspheres. Due to the surface modification by CaHA beads, CaHA/PLGA microspheres exhibit improved cell adhesion, proliferation, and low inflammatory response, as well as enhanced collagen deposition. In vivo studies show that, compared to commercial PLLA microspheres, CaHA/PLGA microspheres provide tissue support as long as 12 weeks with degradation stability, and significantly promote collagen network formation, supporting their long-lasting filling performance. Transcriptome sequencing indicates that CaHA/PLGA microspheres enhance calcium/TGF-β and chemokine signaling pathways in adipose-derived stem cells, facilitating cell migration, cytokine production, and extracellular collagen deposition. Overall, mossy-textured CaHA/PLGA microspheres provide a promising new strategy for soft tissue augmentation and reconstruction.
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