Evidence map›Paper›PMID 41531459›Full record

ArticleThe American journal of geriatric psychiatry. Open science, education, and practice2025

Mild Behavioral Impairment is Associated With Incident Cognitive Decline Among Dementia-Free, Racially Diverse Older Adults: Data From the African Americans Fighting Alzheimer's in Midlife (AA-FAIM) Study.

Barbara L Fischer, Carol A Van Hulle, Derek L Norton, Mary F Wyman, Gilda Ennis, Nickolas H Lambrou, Shenikqua Bouges, Diane C Gooding, Carey E Gleason

Abstract read
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In one paragraph

Article in The American journal of geriatric psychiatry. Open science, education, and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Barbara L FischerDepartment of Neurology (BLF), University of Wisconsin-Madison, Madison, WI; Geriatric Research Education and Clinical Center (GRECC) Wm. S. Middleton VA Hospital (BLF, SB, CEG), Madison, WI; Wisconsin Alzheimer's Institute (CAVH, NHL, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Wisconsin Alzheimer's Disease Research Center (CAVH, DLN, SB, DCG, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Division of Geriatrics and Gerontology (CAVH, DLN, MFW, GE, SB, DCG, CEG), Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Department of Biostatistics and Medical Informatics (DLN), University of Wisconsin-Madison, Madison, WI; and the Department of Psychology (DCG), University of Wisconsin-Madison, Madison, WI.
Carol A Van HulleDepartment of Neurology (BLF), University of Wisconsin-Madison, Madison, WI; Geriatric Research Education and Clinical Center (GRECC) Wm. S. Middleton VA Hospital (BLF, SB, CEG), Madison, WI; Wisconsin Alzheimer's Institute (CAVH, NHL, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Wisconsin Alzheimer's Disease Research Center (CAVH, DLN, SB, DCG, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Division of Geriatrics and Gerontology (CAVH, DLN, MFW, GE, SB, DCG, CEG), Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Department of Biostatistics and Medical Informatics (DLN), University of Wisconsin-Madison, Madison, WI; and the Department of Psychology (DCG), University of Wisconsin-Madison, Madison, WI.
Derek L NortonDepartment of Neurology (BLF), University of Wisconsin-Madison, Madison, WI; Geriatric Research Education and Clinical Center (GRECC) Wm. S. Middleton VA Hospital (BLF, SB, CEG), Madison, WI; Wisconsin Alzheimer's Institute (CAVH, NHL, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Wisconsin Alzheimer's Disease Research Center (CAVH, DLN, SB, DCG, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Division of Geriatrics and Gerontology (CAVH, DLN, MFW, GE, SB, DCG, CEG), Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Department of Biostatistics and Medical Informatics (DLN), University of Wisconsin-Madison, Madison, WI; and the Department of Psychology (DCG), University of Wisconsin-Madison, Madison, WI.
Mary F WymanDepartment of Neurology (BLF), University of Wisconsin-Madison, Madison, WI; Geriatric Research Education and Clinical Center (GRECC) Wm. S. Middleton VA Hospital (BLF, SB, CEG), Madison, WI; Wisconsin Alzheimer's Institute (CAVH, NHL, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Wisconsin Alzheimer's Disease Research Center (CAVH, DLN, SB, DCG, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Division of Geriatrics and Gerontology (CAVH, DLN, MFW, GE, SB, DCG, CEG), Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Department of Biostatistics and Medical Informatics (DLN), University of Wisconsin-Madison, Madison, WI; and the Department of Psychology (DCG), University of Wisconsin-Madison, Madison, WI.
Gilda EnnisDepartment of Neurology (BLF), University of Wisconsin-Madison, Madison, WI; Geriatric Research Education and Clinical Center (GRECC) Wm. S. Middleton VA Hospital (BLF, SB, CEG), Madison, WI; Wisconsin Alzheimer's Institute (CAVH, NHL, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Wisconsin Alzheimer's Disease Research Center (CAVH, DLN, SB, DCG, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Division of Geriatrics and Gerontology (CAVH, DLN, MFW, GE, SB, DCG, CEG), Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Department of Biostatistics and Medical Informatics (DLN), University of Wisconsin-Madison, Madison, WI; and the Department of Psychology (DCG), University of Wisconsin-Madison, Madison, WI.
Nickolas H LambrouDepartment of Neurology (BLF), University of Wisconsin-Madison, Madison, WI; Geriatric Research Education and Clinical Center (GRECC) Wm. S. Middleton VA Hospital (BLF, SB, CEG), Madison, WI; Wisconsin Alzheimer's Institute (CAVH, NHL, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Wisconsin Alzheimer's Disease Research Center (CAVH, DLN, SB, DCG, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Division of Geriatrics and Gerontology (CAVH, DLN, MFW, GE, SB, DCG, CEG), Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Department of Biostatistics and Medical Informatics (DLN), University of Wisconsin-Madison, Madison, WI; and the Department of Psychology (DCG), University of Wisconsin-Madison, Madison, WI.
Shenikqua BougesDepartment of Neurology (BLF), University of Wisconsin-Madison, Madison, WI; Geriatric Research Education and Clinical Center (GRECC) Wm. S. Middleton VA Hospital (BLF, SB, CEG), Madison, WI; Wisconsin Alzheimer's Institute (CAVH, NHL, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Wisconsin Alzheimer's Disease Research Center (CAVH, DLN, SB, DCG, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Division of Geriatrics and Gerontology (CAVH, DLN, MFW, GE, SB, DCG, CEG), Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Department of Biostatistics and Medical Informatics (DLN), University of Wisconsin-Madison, Madison, WI; and the Department of Psychology (DCG), University of Wisconsin-Madison, Madison, WI.
Diane C GoodingDepartment of Neurology (BLF), University of Wisconsin-Madison, Madison, WI; Geriatric Research Education and Clinical Center (GRECC) Wm. S. Middleton VA Hospital (BLF, SB, CEG), Madison, WI; Wisconsin Alzheimer's Institute (CAVH, NHL, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Wisconsin Alzheimer's Disease Research Center (CAVH, DLN, SB, DCG, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Division of Geriatrics and Gerontology (CAVH, DLN, MFW, GE, SB, DCG, CEG), Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Department of Biostatistics and Medical Informatics (DLN), University of Wisconsin-Madison, Madison, WI; and the Department of Psychology (DCG), University of Wisconsin-Madison, Madison, WI.
Carey E GleasonDepartment of Neurology (BLF), University of Wisconsin-Madison, Madison, WI; Geriatric Research Education and Clinical Center (GRECC) Wm. S. Middleton VA Hospital (BLF, SB, CEG), Madison, WI; Wisconsin Alzheimer's Institute (CAVH, NHL, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Wisconsin Alzheimer's Disease Research Center (CAVH, DLN, SB, DCG, CEG), University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Division of Geriatrics and Gerontology (CAVH, DLN, MFW, GE, SB, DCG, CEG), Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI; Department of Biostatistics and Medical Informatics (DLN), University of Wisconsin-Madison, Madison, WI; and the Department of Psychology (DCG), University of Wisconsin-Madison, Madison, WI.

Funding

Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sanjay Asthana · 2019 to 2026
$34.5M
African Americans Fighting Alzheimer’s in Midlife (AA-FAIM)R01AG054059 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAREY E GLEASON · 2016 to 2026
$15.3M
Addressing Alzheimer's Disease and Related Dementias Disparities: The American Indigenous Cognitive Assessment (AMICA) ProjectR01AG074231 · NIA · UNIVERSITY OF MINNESOTA · PI CAREY E GLEASON, Kristen Jacklin · 2022 to 2026
$10.0M
Indigenous Cultural Understandings of Alzheimer's Disease and Related Dementias - Research and Engagement (I-CARE)R01AG062307 · NIA · UNIVERSITY OF MINNESOTA · PI JACKLIN, KRISTEN · 2021 to 2025
$7.5M
Indigenous Cultural Understandings of Alzheimer's Disease and Related Dementias - Research and Engagement (I-CARE)R56AG062307 · NIA · UNIVERSITY OF MINNESOTA · PI JACKLIN, KRISTEN · 2018 to 2019
$1.5M
NIA NIH HHS P30 AG062715NIA NIH HHS R01 AG054059NIA NIH HHS R01 AG062307NIA NIH HHS R01 AG074231NIA NIH HHS R56 AG062307
6 · The paper itself

Abstract

Objectives: To determine whether MBI associates with worse cognitive performance over time and with incident cognitive decline in an older, racially/ethnically diverse cohort at early stages of cognitive change. Design: This observational cohort study followed participants from the Wisconsin Alzheimer's Disease Research Center Clinical Core (WADRC) for up to 13 visits. Setting: An urban university research center. Participants: Participants from the WADRC Clinical Core were included in this convenience sample if they were without dementia, had undergone at least 1 cognitive assessment, and completed measures of cognitive, clinical and affective function. Measurements: MBI was assessed using the Neuropsychiatric Inventory. Linear mixed effects models (LME) were fit to cognitive outcomes Trailmaking Tests A and B (TMT-A, B) and Wechsler Logical Memory (LM). Cox proportional hazard models assessed whether MBI was related to risk for incident global Clinical Dementia Rating Scale (CDR >0). Results: N = 584 participants with mean age 64.6 years, range 46-92.6 years, 59.4% female and 17% African American. LME results indicated participants with MBI exhibited worse age-associated decline on TMT-B, compared to those without MBI (beta=0.008, p = 0.01, CI: 0.002, 0.01, t(337) = 2.4, p = 0.01). MBI at baseline was associated with a significant hazard ratio (HR) indicating an increased risk of decline on the CDR (HR: 2.84; HR 95% CI: 1.68 - 4.81; p = 0.0001). Conclusions: MBI associated with worse cognitive performance and incident cognitive decline in a racially diverse, older adult sample at early stages of cognitive change. Increased awareness of the late life emergence of neuropsychiatric symptoms is warranted to assist in identification and improve prognostication and treatment of neurodegenerative disease.

Indexed as

African Americans FightingAlzheimer’s in Midlife (AA-FAIM)cognitive declineearly disease stagesmild behavioral impairment (MBI)neuropsychiatric symptomsolder adultsracially diverse

Identifiers

PMID41531459
PMCPMC12795589

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.