ArticleCureus2026
Effects of Antiplatelet and Anticoagulant Therapy on Emergency Surgical Outcomes in Orthopedic Trauma Patients With Cardiac Comorbidities.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmergency orthopedic trauma surgery in patients with cardiac comorbidities presents a major clinical challenge due to the widespread use of antiplatelet and anticoagulant therapy.
objectiveTo evaluate the impact of antiplatelet and anticoagulant therapy on perioperative bleeding, surgical timing, postoperative complications, and mortality in orthopedic trauma patients with cardiac comorbidities.
methodsThis retrospective cross-sectional study was conducted at Jinnah Hospital, Lahore, from June 2024 to June 2025. It included 246 patients with cardiac comorbidities who underwent emergency orthopedic trauma surgery. Emergency surgery was defined as operative fixation required within 72 hours of injury based on pain severity, fracture instability, neurovascular risk, or potential displacement. Data were collected on demographics, comorbidities, type of antithrombotic therapy, fracture patterns, surgical timing, intraoperative blood loss, transfusion requirements, postoperative complications, length of stay, and in-hospital mortality.
resultsThe mean age of patients was 64.2±11.8 years, with 60.6% being male. Hip fractures were the most common injury (65.8%). Antiplatelet therapy was used in 55.7% of patients, anticoagulants in 31.7%, and combined therapy in 12.6%. Patients on dual antiplatelet therapy and anticoagulants had significantly greater blood loss (742±235 ml and 689±228 ml, respectively) and higher transfusion requirements compared with aspirin-only patients. Surgical delay was longest in patients on direct oral anticoagulants (56.2±14.9 hours). Postoperative complications included wound hematoma (13.8%), infection (7.7%), thromboembolic events (6.9%), and reoperation (4.5%). Overall mortality was 8.5%, highest among patients on dual antiplatelet therapy (11.7%). Logistic regression identified dual antiplatelet therapy (OR 2.4, 95% CI 1.2-4.8), anticoagulant therapy (OR 1.9, 95% CI 1.1-3.6), surgical delay >48 hours (OR 2.8, 95% CI 1.5-5.1), and age >70 years (OR 2.2, 95% CI 1.1-4.3) as independent predictors of adverse outcomes.
conclusionAntiplatelet and anticoagulant therapy significantly influence emergency surgical outcomes in orthopedic trauma patients with cardiac comorbidities. These findings support the need for standardized multidisciplinary perioperative protocols including early cardiology input, structured antithrombotic management pathways, and expedited surgical planning to optimize outcomes in this high-risk population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.