ArticleMacromolecular bioscience2026
RGD Modification of Poly(2-oxazoline) Cryogels: Investigation of Material Properties and Cellular Adhesion.
Article in Macromolecular bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- RGD Modification of Poly(2-oxazoline) Cryogels: Investigation of Material Properties and Cellular Adhesion.Macromolecular bioscience · 2026Article
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10 authors.
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Abstract
In this study, we demonstrate the preparation of a poly(2-oxazoline) based RGD-functionalized cryogels and cell culture studies on these cryogels. The present work also involves the investigation of cryogels with ethyl side chains (CG(B-Et-PipA)) and primary amino groups in their side chain (CG(B-Am-PipA)) which have been synthesized previously. CG(B-Am-PipA) was subsequently functionalized with a peptide containing an RGD motif (GCWGRGDSP), resulting in the formation of CG(B-Am-PipA/RGD). The coupling was verified by confocal laser-scanning microscopy (CLSM), fourier-transform infrared spectroscopy (FT-IR), high-resolution magic-angle-spinning (HR-MAS) NMR spectroscopy, and gravimetrical measurements. The degree of functionalization was found to be around 45%. The functionalized gels exhibited a change in their thermal properties, which was examined using thermogravimetric analysis (TGA). Rheological analysis was employed to study the mechanical properties and showed the formation of a stiffer material after peptide coupling. Swelling tests revealed a reduced swelling behavior for CG(B-Am-PipA/RGD). Cell biological investigations were conducted with L929 cells which were incubated with the samples CG(B-Et-PipA)RhoB, CG(B-Am-PipA)RhoB and CG(B-Am-PipA/RGD)RhoB. CLSM measurements after 0.5, 1, 2 and 6 h revealed an initial adhesion for both CG(B-Am-PipA)RhoB and CG(B-Am-PipA/RGD)RhoB, with the RGD-functionalized cryogel exhibiting the fastest cell adhesion and the most pronounced adherent phenotype, characterized by distinctly spread cell bodies as confirmed by cell area measurements. Cultivation of cells over a period of 7 days, analyzed by scanning electron microscopy (SEM), further showed pronounced cellular adhesion exclusively on CG(B-Am-PipA) and CG(B-Am-PipA/RGD).
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