Evidence map›Paper›PMID 41531407›Full record

ArticleWomen's health nursing (Seoul, Korea)2025

Factors affecting menstrual cycle changes following COVID-19 vaccination in Korean women of reproductive age: an exploratory correlational study.

Sunhee Lee, Kyung-Eui Bae, Hyun-Jung Park

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Article in Women's health nursing (Seoul, Korea), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

3 authors.

Sunhee LeeDepartment of Nursing, Baekseok Cultural University, Cheonan, Korea.
Kyung-Eui BaeDepartment of Nursing, Dongseo University, Busan, Korea.
Hyun-Jung ParkDepartment of Nursing, Pyeongtaek University, Pyeongtaek, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to examine the impact of coronavirus disease 2019 (COVID-19) vaccination on menstrual cycle changes among Korean women of reproductive age.

methodsThis exploratory correlational study used data from an online, self-administered questionnaire obtained from the Korea Social Science Data Center database. The survey assessed menstrual cycle changes following COVID-19 vaccination among Korean women of reproductive age (15-49 years) who were menstruating regularly and had a history of COVID-19 vaccination. Data were collected between February and March 2023. A total of 227 participants who completed the online questionnaire were included in the analysis.

resultsThe risk of menstrual cycle changes was higher among older women (reference group: 40-49 years; 15-19 years: odds ratio [OR], 0.25 [p=.006]; 30-39 years: OR, 0.03 [p=.030]), women with obesity (reference group: body mass index [BMI] >23 kg/m2; BMI <18.5 kg/m2: OR, 0.03 [p=.030]; BMI 18.5-22.9: OR, 0.002 [p=.002]), and unmarried women (OR, 3.02). Increased risk was also observed among participants with a history of COVID-19 infection (OR, 3.46; p=.015), those who received the second or lower dose of the vaccine, and those reporting excessive menstrual flow (OR, 2.07; p=.015), intermenstrual symptoms (OR, 2.72; p=.037), or irregular menstruation (OR; 5.37, p<.001).

conclusionMenstrual cycle changes following COVID-19 vaccination appear to be influenced by multiple factors, particularly the interaction between a history of irregular menstruation and environmental conditions. Further longitudinal studies and tailored management strategies for specific subgroups, including unmarried and obese women, are needed to support women's health and quality of life.

Indexed as

COVID-19COVID-19 VaccinesMenstrual CycleVaccinationAdolescentAdultFemaleHumansMiddle AgedRepublic of KoreaSARS-CoV-2Surveys and QuestionnairesYoung AdultCOVID-19 VaccinesCOVID-19 vaccinesKoreaMenstrual cycleReproductive healthUterine hemorrhage

Identifiers

PMID41531407
PMCPMC12835451

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.