Evidence map›Paper›PMID 41531327›Full record

ArticleJournal of pathology and translational medicine2026

PSMA expression in hepatic colorectal cancer metastasis.

Eundong Park, Michel Kmeid, Xin Wang, Haiyan Qiu, Clifton G Fulmer, Marcello P Toscano, Nusret Bekir Subasi, Maciej Gracz, Hwajeong Lee

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Article in Journal of pathology and translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Incidental detection of PDAC viaFrontiers in nuclear medicine · 2026
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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Eundong ParkPathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Michel KmeidDepartment of Pathology, Cleveland Clinic, Cleveland, OH, USA.
Xin WangPathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Haiyan QiuPathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Clifton G FulmerDepartment of Pathology, Cleveland Clinic, Cleveland, OH, USA.
Marcello P ToscanoDepartment of Pathology, Cleveland Clinic, Cleveland, OH, USA.
Nusret Bekir SubasiPathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Maciej GraczPathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Hwajeong LeePathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstate-specific membrane antigen (PSMA) is expressed in the neovasculature of various malignancies, such as colorectal cancer (CRC) and hepatocellular carcinoma (HCC). However, PSMA expression in hepatic CRC metastasis has not been studied in detail.

methodsThe PSMA expression in primary CRC and corresponding hepatic metastasis was evaluated by immunohistochemistry in a metastatic CRC cohort (n = 56), which was divided into subgroups according to treatment history and timing of metastasis. Demographic and histological characteristics of primary CRC were collected and their relationships with PSMA expression were examined. Additionally, the PSMA expression in resected HCC (n = 76) was compared with that of hepatic CRC metastasis.

resultsIn primary CRC, PSMA level showed a positive association with tumor size. Lower PSMA expression in hepatic metastasis was associated with higher primary CRC grade, advanced pTNM stage at the time of CRC resection, presence of tumor deposit, and unresectability of metastatic lesion. PSMA expression in primary CRC correlated with that in hepatic metastasis only in concurrent and untreated metastasis subgroup. PSMA expression in primary CRC and hepatic metastasis, regardless of treatment history and timing of metastasis, was not significantly different from that of HCC.

conclusionsSeveral adverse pathological features of primary CRC were associated with a lower PSMA expression in hepatic metastasis. PSMA expression in hepatic metastasis correlated with that of primary CRC only in concurrent and untreated subgroup. Primary HCC and hepatic CRC metastasis show comparable levels of PSMA expression.

Indexed as

Colorectal neoplasmsHepatic metastasisHepatocellular carcinomaImmunohistochemistryPSMA

Identifiers

PMID41531327
PMCPMC13586503

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