Evidence map›Paper›PMID 41531279›Full record

ArticleMicrobiologyOpen2026

Efficacy, Safety and Biological Characteristics of Formulation Based on Essential Oil Against Co-Infections of Herpes Simplex Virus-1 and Candida albicans.

Maura Di Vito, Domiziana Coggiatti, Marilena La Sorda, Stefania Garzoli, Giulia Lombardini, Debora Talamonti, Scilla Pizzarelli, Abdesselam Zhiri, Margherita Cacaci, Riccardo Torelli and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MicrobiologyOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maura Di VitoDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.
Domiziana CoggiattiDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.
Marilena La SordaDipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
Stefania GarzoliDipartimento di Chimica e Tecnologie del Farmaco, Università di Roma Sapienza, Rome, Italy.ORCID 0000-0001-8535-0533
Giulia LombardiniDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.
Debora TalamontiDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.
Scilla PizzarelliKnowledge Unit (Documentation, Library), Istituto Superiore di Sanità, Rome, Italy.
Abdesselam ZhiriR&D Department, Pranarom international 37, Avenue des Artisans, Ghislemghien, Belgium.
Margherita CacaciDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.
Riccardo TorelliDipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
Maurizio SanguinettiDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID 0000-0002-9780-7059
Francesca BugliDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.

Funding

EU funding within the MUR PNRR Extended Partnership Initiative on Emerging Infectious Diseases INF-ACTEU funding within the MUR PNRR Extended Partnership Initiative on Emerging Infectious Diseases PE00000007Linea di finanziamento di ateneo D1, Università Cattolica del Sacro Cuore
6 · The paper itself

Abstract

Oral coinfections involving herpes simplex virus (HSV) and Candida albicans can potentially interact and exacerbate each other. Starting from bibliographical investigation, this study aimed to examine the effectiveness of some essential oils (EOs), and their commercial formulations, both against C. albicans and HSV-1, identifying their antimicrobial, anti-inflammatory and allergenic potential. A preliminary review examined essential oils' efficacy against HSV-1. Broth microdilution tested 14 EOs, a commercial formulation (LA), and a homemade one (MIX) against three fungal strains. The quality of LA, MIX and single EOs was assessed by Solid Phase Microextraction (SPME) sampling coupled with gas chromatography-mass spectrometry (GC-MS) analysis. To assess the allergenic activity of MIX, LA, and single EOs a Basophil Activation Test (BAT) was standardized. ELISA tests were done to evaluate the anti-inflammatory activity. The bibliographic search highlighted seven EOs active against HSV-1. Four EOs showing strong antifungal activity were blended, following IFRA lip-application limits, to create a formulation (MIX) for comparison with a commercial herpes treatment (LA). Formulations were active against HSV-1, able to modulate the expression of pro (TNF-α

Indexed as

Antifungal AgentsAntiviral AgentsCandida albicansCandidiasisCoinfectionHerpes SimplexHerpesvirus 1, HumanOils, VolatileAnimalsAnti-Inflammatory AgentsHumansMicrobial Sensitivity TestsAntifungal AgentsAnti-Inflammatory AgentsAntiviral AgentsOils, Volatileantifungal activityanti‐inflammatory activityantiviral activitybasophil activation testco‐infection

Identifiers

PMID41531279
PMCPMC12800574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.