Evidence map›Paper›PMID 41531204›Full record

ReviewInternational journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience2026

The Ontogenetic Development of Rapid Eye Movement Sleep in Early Life and Its Regulatory Mechanisms.

Xiu-Juan Zhang, Xu-Hao Gao, An-Hong Wang, Cai-Qin Wang, Jia Liu, Yan-Li Hu, Bo-Wen Duan, Hai-Yun Huang, Jin-Xian Gao

Abstract readReview
In one paragraph

Review in International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. The Ontogenetic Development of Rapid Eye Movement Sleep in Early Life and Its Regulatory Mechanisms.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiu-Juan ZhangDepartment of Pharmacy, Gansu Provincial Hospital, Lanzhou, China.
Xu-Hao GaoDepartment of Cardiology, Jingning County Peoples Hospital, Jingning, China.
An-Hong WangDepartment of Pharmacy, Gansu Provincial Hospital, Lanzhou, China.
Cai-Qin WangDepartment of Pharmacy, Gansu Provincial Hospital, Lanzhou, China.
Jia LiuDepartment of Pharmacy, Gansu Provincial Hospital, Lanzhou, China.
Yan-Li HuDepartment of Pharmacy, Gansu Provincial Hospital, Lanzhou, China.
Bo-Wen DuanDepartment of Pharmacy, Gansu Provincial Hospital, Lanzhou, China.
Hai-Yun HuangDepartment of Breast, Gansu Provincial Hospital, Lanzhou, China.
Jin-Xian GaoDepartment of Pharmacy, Gansu Provincial Hospital, Lanzhou, China.ORCID https://orcid.org/0000-0003-1572-2666

Funding

National Natural Science Foundation of China 82560273the Gansu Medical Products Administration 2024GSMPA029The Internal Research Fund of Gansu Provincial People's Hospital 24GSSYA-6The Program of Gansu Provincial Science and Technology Department 20JR10RA383The Program of Gansu Provincial Science and Technology Department 24JRRA1056The Program of Gansu Provincial Science and Technology Department 25JRRA875
6 · The paper itself

Abstract

Rapid eye movement (REM) sleep, also known as paradoxical sleep (PS), was first identified in humans and cats in the late 1950s. It is hypothesized to contribute to brain development by providing endogenous neural activity patterns that coincide with critical periods of maturation. We summarize the remarkable alterations in polysomnographic data, EEG power spectral analysis, and behavioural patterns during early-life REM sleep, as well as the subsequent maturation of these features and the development of regulatory mechanisms. REM sleep disturbances in early life are linked to neurodevelopmental disorders. Our review aims to elucidate changes in the main characteristics during REM sleep development and its evolutionary connection with brain development, ultimately providing a basis for promoting the prevention and treatment of various neurodevelopmental disorders.

Indexed as

BrainSleep, REMAnimalsElectroencephalographyHumansNeurodevelopmentinfantontogenetic developmentrapid eye movement (REM)sleep

Identifiers

PMID41531204
PMCPMC12800732

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.