Evidence map›Paper›PMID 41531201›Full record

ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Effectiveness of Punch Grafting in Promoting Healing and Reducing Pain in Hard-to-Heal Leg Ulcers.

Julia Neuenschwander, Dieter O Mayer, Ramon Lang, Caroline Staub-Buset, Mirjam Nägeli, Jürg Hafner

Abstract read
In one paragraph

Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Clinical Applications of Punch-Based Techniques in Dermatologic Surgery.Clinical, cosmetic and investigational dermatology · 2026
    Review
  2. Effectiveness of Punch Grafting in Promoting Healing and Reducing Pain in Hard-to-Heal Leg Ulcers.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Julia NeuenschwanderDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Dieter O MayerDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Ramon LangDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Caroline Staub-BusetDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Mirjam NägeliDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Jürg HafnerDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 20% of chronic leg ulcers remain recalcitrant despite treatment of underlying factors and best standard of wound care. This study aimed to evaluate the effectiveness of partial-thickness punch grafting in promoting healing and reducing pain in patients with chronic, hard-to-heal leg ulcers of various causes. In this single-centre, retrospective cohort study, 93 patients were treated between January 2016 and December 2024, with follow-up at 1, 3, 6 and 12 months. The primary outcome was complete wound healing, while secondary outcomes included pain reduction and wound surface changes. At 12 months, 78/88 analysed patients (88.6%) achieved complete healing of the target ulcer. Pain levels improved substantially, with the proportion of pain-free patients increasing from 17.6% at baseline to 76.3% at 6 months. Donor site complications were minimal (6.5%) and cosmetic outcomes were excellent. Recurrence after 12-month follow-up occurred in only 9% of healed ulcers within 12 months. These results confirm that partial-thickness punch grafting is a highly effective and minimally invasive technique for treating hard-to-heal leg ulcers, delivering durable healing, rapid pain relief and low morbidity. This study provides new long-term data supporting the broad clinical utility of punch grafting across diverse ulcer types.

Indexed as

Leg UlcerPainSkin TransplantationWound HealingAgedAged, 80 and overChronic DiseaseFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment Outcomechronic leg ulcerhard‐to‐heal leg ulcerpunch graftpunch graftingrecalcitrant leg ulcerskin grafting

Identifiers

PMID41531201
PMCPMC12800727

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.