Evidence map›Paper›PMID 41531181›Full record

Trial reportJournal of the American Geriatrics Society2026

The Effect of Vitamin D

Toni Rikkonen, Sari Hantunen, Heikki Kröger, Christel Lamberg-Allardt, JoAnn E Manson, Tarja Nurmi, Marjo Tuppurainen, Ari Voutilainen, Tomi-Pekka Tuomainen, Jyrki K Virtanen

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Geriatrics Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01463813 (Finnish Vitamin D Trial), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01463813 nacompletednot on this map

Finnish Vitamin D Trial (FIND)

TypeinterventionalSponsorUniversity of Eastern FinlandRan2012 to 2018Enrolled2,495ConditionsCardiovascular Diseases, CancerArmsVitamin D3, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Toni RikkonenInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0001-5948-1222
Sari HantunenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0001-5330-3847
Heikki KrögerDepartment of Orthopaedics, Traumatology and Hand Surgery, Kuopio University Hospital, Kuopio, Finland.
Christel Lamberg-AllardtDepartment of Food and Nutrition, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-7326-1904
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital Harvard Medical School and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-9426-7595
Tarja NurmiInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Marjo TuppurainenInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.ORCID 0009-0005-6391-3071
Ari VoutilainenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-0664-2675
Tomi-Pekka TuomainenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Jyrki K VirtanenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-0648-999X

Funding

Academy of Finland 137826DiabetestutkimussäätiöItä-Suomen YliopistoJuho Vainion SäätiöMedicinska Understödsföreningen Liv och HälsaPäivikki ja Sakari Sohlbergin SäätiöSuomen KulttuurirahastoSydäntutkimussäätiö
6 · The paper itself

Abstract

backgroundThe impact of vitamin D on fall incidence remains controversial. We studied the effect of 5 years of vitamin D

methodsThe study included 2495 participants, men aged ≥ 60 and women aged ≥ 65, who were randomized into three arms: 1600 IU/day or 3200 IU/day of vitamin D

resultsOver the 5-year follow-up, a similar fall risk of 55% and fall-injury risk of 11% were observed in the placebo, 1600 IU/day, and 3200 IU/day arms, with the mean number of falls and fall-injuries per person-year of 1.26 (95% CI 1.14-1.38) and 0.07 (95% CI 0.06-0.08), respectively. Age, sex, or BMI did not modify the results. In the random subgroup, the mean baseline serum 25(OH)D concentration was 75 nmol/L (SD 18). After 12 months, the concentrations were 73, 100, and 120 nmol/L in the placebo, 1600 IU/day, and 3200 IU/day arms, respectively.

conclusionsFive-year vitamin D

trial registrationClinicalTrials.gov: NCT01463813, https://clinicaltrials.gov/ct2/show/NCT01463813.

Indexed as

Accidental FallsCholecalciferolDietary SupplementsVitaminsAgedDouble-Blind MethodFemaleFinlandFollow-Up StudiesHumansIncidenceMaleMiddle AgedRisk FactorsCholecalciferolVitaminsfallsrandomized trialsupplementationvitamin D

Identifiers

PMID41531181
PMCPMC13266444

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.