Evidence map›Paper›PMID 41531179›Full record

ArticleJournal of neuroscience research2026

G Protein-Coupled Receptor Kinase 5 (GRK5) Modulates Nociceptin/Orphanin FQ Opioid (NOP) Receptor Desensitization in Rat Sympathetic Neurons.

Mohamed Farrag, Marwa Soliman, Saifeldin Mahmoud, Lauren Miller, Paul B Herold, Kristen Brandt, Victor Ruiz-Velasco

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohamed FarragDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Marwa SolimanDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Saifeldin MahmoudDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Lauren MillerDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Paul B HeroldDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Kristen BrandtDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Victor Ruiz-VelascoDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-3614-5028

Funding

National Heart Lung and Blood Institute HL156513NIH HHS DA025574
6 · The paper itself

Abstract

Stimulation of nociceptin/orphanin FQ peptide (NOP) opioid receptors by the endogenous ligand nociceptin (Noc) leads to voltage-gated Ca

Indexed as

G-Protein-Coupled Receptor Kinase 5NeuronsReceptors, OpioidStellate GanglionAnimalsCells, CulturedG-Protein-Coupled Receptor Kinase 2MaleNociceptinNociceptin ReceptorOpioid PeptidesRatsRats, Sprague-DawleyRNA, Small InterferingG-Protein-Coupled Receptor Kinase 2G-Protein-Coupled Receptor Kinase 5Grk2 protein, ratGrk5 protein, ratNociceptinNociceptin ReceptorOpioid PeptidesOprl1 protein, ratReceptors, OpioidRNA, Small InterferingG protein‐coupled receptor kinasenociceptinnociceptin/orphanin FQ opioid (NOP) receptorN‐type voltage‐gated Ca2+ channel (CaV2.2)stellate ganglion neuronswhole‐cell patch‐clamp technique

Identifiers

PMID41531179
PMCPMC12800729

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.