Evidence map›Paper›PMID 41531153›Full record

ArticleClinical and experimental pediatrics2026

Influence of atrial septal defect on mitral valve growth after repair of coarctation of the aorta or an interrupted aortic arch in infants.

Yi-Chia Wang, Heng-Wen Chou, Chi-Hsiang Huang, Hsing-Hao Huang, Yih-Sharng Chen, En-Ting Wu, Shyh-Jye Chen, Ming-Tai Lin, Shuenn-Nan Chiu, Shu-Chien Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Yi-Chia WangDepartment of Anesthesiology, National Taiwan University Hospital, Taiwan.
Heng-Wen ChouDepartment of Surgery, National Taiwan University Hospital, Taiwan.
Chi-Hsiang HuangDepartment of Anesthesiology, National Taiwan University Hospital, Taiwan.
Hsing-Hao HuangDepartment of Anesthesiology, National Taiwan University Hospital, Taiwan.
Yih-Sharng ChenDepartment of Surgery, National Taiwan University Hospital, Taiwan.
En-Ting WuDepartment of Pediatrics, National Taiwan University Hospital, Taiwan.
Shyh-Jye ChenDepartment of Radiology, National Taiwan University Hospital, Taiwan.
Ming-Tai LinDepartment of Pediatrics, National Taiwan University Hospital, Taiwan.
Shuenn-Nan ChiuDepartment of Pediatrics, National Taiwan University Hospital, Taiwan.
Shu-Chien HuangDepartment of Surgery, National Taiwan University Hospital, Taiwan.

Funding

Ministry of Science and Technology, Taiwan MOST-112-2314-B-002-180-Ministry of Science and Technology, Taiwan MOST-113-2314-B-002-271-Ministry of Science and Technology, Taiwan NSTC-113-2314-B-002-150-
6 · The paper itself

Abstract

backgroundPatients with coarctation of the aorta (CoA) and an interrupted aortic arch (IAA) may present with small mitral valves (MVs) and a reduced left ventricular (LV) volume. Biventricular repair (BVR) in these patients is dependent on adequate size of the left cardiac structures. PURPOSE: This study evaluated the impact of the hemodynamic characteristics of atrial septal defects (ASDs) on MV growth following surgical repair.

methodsWe retrospectively reviewed the data of patients diagnosed with CoA or IAA between 2007 and 2024. The z score for MV size measured 6 months postoperatively (Z2) was compared with the preoperative MV size (Z1). The factors associated with MV growth were also studied.

resultsA total of 161 patients with CoA or IAA were included. Transthoracic echocardiography was used to assess the MV and LV dimensions preoperatively and 6 months postoperatively. Of the cohort, 155 (96.3%) underwent initial BVR and 6 underwent single-ventricle palliation. MV z scores significantly increased following BVR (mean change: +0.45±1.35; P<0.001) but decreased after single-ventricle repair (-0.56±0.49, P=0.04). Multivariate analysis identified the initial MV z score and ASD pressure gradient as independent predictors of MV growth (R2=0.39).

conclusionAnnular growth of the MV was not observed in patients who underwent single-ventricle palliation. In contrast, among patients who achieved BVR, those with a small preoperative MV annulus and low ASD pressure gradient demonstrated subsequent catch-up MV growth, suggesting that adequate left-sided preload is essential for MV development.

Indexed as

Aortic ArchAortic coarctationAtrial heart septal defectsHypoplastic Left Heart SyndromeInterruptedMitral valve

Identifiers

PMID41531153
PMCPMC13076050

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.