Trial reportJournal of clinical periodontology2026
Adjunctive Systemic Amoxicillin and Metronidazole Following Surgical Peri-Implantitis Treatment: A Single-Blind Randomised Controlled Trial With a 1-Year Follow-Up.
Trial report in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
aimTo analyse the effect of systemic amoxicillin and metronidazole on surgical peri-implantitis treatment with a follow-up period of 1 year. MATERIALS AND
methodsFifty-nine patients were randomly assigned to receive peri-implantitis surgery supplemented with (29 patients; test) or without (30 patients; control) systemic amoxicillin and metronidazole, in cases with no, one-wall or two-wall bony defects. Primary outcomes were mean peri-implant probing pocket depth (PPD) and mean peri-implant bleeding on probing (BOP); secondary outcomes included disease resolution (composite treatment outcome: residual probing depths ≤ 5 mm; no BOP in one or more probing site; no suppuration on probing), suppuration on probing (SOP) and radiographic marginal bone levels (MBLs), evaluated 3, 6, 9 and 12 months postoperatively (T3, T6, T9, T12). Linear and logistic mixed-effects models were employed.
resultsBetween-group analyses showed that BOP was significantly lower in the test group compared to the control group at T9 (β = -10.57%, 95% CI: -20.17 to -0.97, p = 0.03) and T12 (β = -14.47%, 95% CI: -25.9 to -3.04, p = 0.01). No other parameters in the mixed-effects models showed statistically significant differences between groups at any timepoint.
conclusionAccess-flap peri-implantitis surgery supplemented with systemic amoxicillin and metronidazole led to a statistically significant reduction in peri-implant BOP after 1 year, whereas no other parameters showed statistically significant differences between groups at any timepoint. The clinical implications of these differences should be interpreted with caution, as the isolated short-term effect does not translate into broader or sustained clinical benefit and must be weighed against the risks associated with systemic antibiotic use.
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