Evidence map›Paper›PMID 41531144›Full record

ArticleJournal of the American Geriatrics Society2026

Sensorimotor Impairment and Incident Dementia in the US Medicare Beneficiaries.

Anis Davoudi, Ryan J Dougherty, Amal A Wanigatunga, Yuri Agrawal, Nicholas S Reed, Joshua R Ehrlich, Alden L Gross, Jennifer A Schrack

Erratum issuedAbstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Anis DavoudiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-3383-9481
Ryan J DoughertyDepartment of Kinesiology and Health, Rutgers University, New Brunswick, New Jersey, USA.
Amal A WanigatungaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-5763-5184
Yuri AgrawalDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado, Aurora, Colorado, USA.
Nicholas S ReedDepartment of Otolaryngology-Head and Neck Surgery, New York University Grossman School of Medicine, New York, New York, USA.
Joshua R EhrlichSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-0607-3564
Alden L GrossDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Jennifer A SchrackDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.

Funding

The National Health and Trends StudyU01AG032947 · NIA · JOHNS HOPKINS UNIVERSITY · PI VICKI A. FREEDMAN, JENNIFER ANN SCHRACK · 2008 to 2026
$169.4M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Abhay Moghekar · 2020 to 2026
$29.3M
Leveraging a natural experiment to estimate the causal impact of blood sugar on dementia and cognition in IndiaR01AG051125 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jinkook Lee · 2015 to 2026
$26.8M
Socioeconomic, Cardiovascular, and Psychosocial Sources of Cross-National Variation in Cognitive Health Among Older AdultsR01AG070953 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alden L. Gross, Lindsay C Kobayashi · 2021 to 2026
$4.6M
Contribution of sensorimotor function to risk and pathogenic mechanisms of Alzheimer's disease and related dementiasR01AG061786 · NIA · JOHNS HOPKINS UNIVERSITY · PI AGRAWAL, YURI, LIN, FRANK R · 2019 to 2023
$3.7M
Vision Impairment in the National Health and Aging Trends StudyR01EY034479 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joshua Robert Ehrlich · 2023 to 2026
$2.6M
Mild Cognitive Impairment and Alzheimer's Disease and Related Dementias: Cross-national longitudinal prognosis and risk factorsRF1AG088009 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ARCE, MIGUEL, BRICENO, EMILY MARIE · 2024 to 2024
$2.3M
Sensory Aging, Late-Life Wellbeing, and ADRD Research Infrastructure to Catalyze Practice and PolicyR61AG089063 · NIA · JOHNS HOPKINS UNIVERSITY · PI DEAL, JENNIFER ANNE, EHRLICH, JOSHUA ROBERT · 2024 to 2025
$1.6M
The START trial: a proof-of-concept sedentary reduction program for prefrail older adultsK01AG076967 · NIA · JOHNS HOPKINS UNIVERSITY · PI Amal Asiri Wanigatunga · 2022 to 2026
$651k
Energy expenditure, cognitive function, and biomarker features of Alzheimer's diseaseK01AG080122 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI Ryan James Dougherty · 2023 to 2026
$501k
NEI NIH HHS R01EY034479NIA NIH HHS K01AG076967NIA NIH HHS K01 AG080122NIA NIH HHS K01AG080122NIA NIH HHS P30 AG066507NIA NIH HHS R01AG051125NIA NIH HHS R01AG061786NIA NIH HHS R01AG070953NIA NIH HHS R61AG089063NIA NIH HHS RF1AG088009NIA NIH HHS U01AG032947
6 · The paper itself

Abstract

backgroundSensorimotor impairments, including sensory (vision and hearing) and motor (standing balance, gait, chair stands, grip strength) deficits, are prevalent in older adults and are associated with an increased risk of dementia. Understanding the individual and combined effects of these impairments on dementia risk may enhance early detection and preventive strategies. We examined the association between baseline sensory difficulties and motor impairments, individually and collectively, with dementia over up to 11 years.

methodsWe used data from the National Health and Aging Trends Study (NHATS), a nationally representative study of US community-dwelling Medicare beneficiaries aged ≥ 65 years. Participants cognitively unimpaired at baseline in 2011 were followed annually through 2022. Baseline exposures included self-reported sensory difficulties (vision, hearing) and objectively measured motor impairments (standing balance, gait speed, chair stand, grip strength). The primary outcome was incident dementia, assessed annually based on NHATS consensus procedures. Survey-weighted Cox proportional hazards models assessed the association between each impairment and number of impairments and incident dementia, adjusting for demographics and clinical conditions.

resultsThe analytic sample included 3847 participants (weighted average age 73.9 (95% CI, 73.7-74.1) years, 56% women). Over an average follow-up of 5.2 years, vision difficulty (HR = 1.34; 95% CI, 1.13-1.60), standing balance impairment (HR = 1.23; 95% CI, 1.10-1.39), slow gait speed (HR = 1.49; 95% CI, 1.34-1.67), impaired chair stand performance (HR = 1.31; 95% CI, 1.18-1.47), and weak grip strength (HR = 1.31; 95% CI, 1.13-1.51) were each independently associated with higher dementia risk. Compared to no impairments, dementia risk increased significantly with three or more sensorimotor impairments (HR = 1.44 to 1.96).

conclusionsIn this nationally representative cohort, vision difficulty and motor impairments were independently associated with increased dementia risk over up to 11 years. The presence of multiple sensory difficulties and motor impairments substantially increased the risk of dementia, emphasizing the importance of their early detection and management to reduce dementia risk.

Indexed as

DementiaMedicareSensation DisordersVision DisordersAgedAged, 80 and overFemaleHumansIncidenceIndependent LivingMalePostural BalanceProportional Hazards ModelsRisk FactorsUnited Statesdementia riskmotor impairmentsensory difficulty

Identifiers

PMID41531144
PMCPMC12911548

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.