Evidence map›Paper›PMID 41531034›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2026

Positive affect as a developmental mediator of early adversity and internalizing psychopathology.

Jamie L Hanson, Dorthea J Adkins, Isabella Kahhale, Sriparna Sen

Abstract read
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Jamie L HansonLearning, Research & Development Center, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-0469-8886
Dorthea J AdkinsLearning, Research & Development Center, University of Pittsburgh, Pittsburgh, PA, USA.
Isabella KahhaleLearning, Research & Development Center, University of Pittsburgh, Pittsburgh, PA, USA.
Sriparna SenLearning, Research & Development Center, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Early Life Adversity and Affective Dynamics: Integrating EMA And Multimodal MRI To Understand Depression RiskR01MH136109 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jamie Lars Hanson · 2025 to 2026
$1.4M
NIMH NIH HHS R01 MH136109NIMH NIH HHS R01MH136109
6 · The paper itself

Abstract

backgroundEarly life adversities (ELAs) including experiences such as abuse, neglect, and household dysfunction are strongly linked to psychopathology; yet, the developmental pathways connecting ELA to externalizing and internalizing psychopathology remain unclear. While most research has focused on threat and negative affect, positive emotions may represent a critical but understudied mechanism linking ELA to mental health outcomes.

methodsUsing data from the Adolescent Brain Cognitive Development (ABCD) study, we examined positive affect trajectories across six timepoints spanning childhood through adolescence (ages 9-10 to 12-13). We employed person-centered trajectory-based clustering to identify distinct patterns in positive affect - independent of ELA exposure - followed by multinomial logistic regression to examine associations between cumulative ELA exposure and trajectory membership. Mediation analyses tested whether positive affect trajectories explained links between ELA and psychopathology outcomes.

resultsFour distinct positive affect trajectories emerged: High-Stable, Declining, Persistently Low, and Volatile (N = 7,457). Higher ELA scores significantly predicted membership in all non-high-stable trajectories, with the strongest association existing for the Persistently Low group (β = .321, p < .001). Mediation analyses revealed that Persistently Low trajectory group membership significantly mediated the relationship between ELA and internalizing problems (indirect effect = 0.030, 95% CI [0.012, 0.056], p = .007), but not externalizing problems (N = 3,927).

conclusionsThis study demonstrates that ELA shapes positive affect development through distinct, heterogeneous pathways rather than uniform effects, with persistently low positive affect representing a specific mechanism linking early adversity to later depression and anxiety. Findings suggest that targeting positive emotional experiences may be a promising intervention strategy for youth exposed to ELA.

Indexed as

Adolescent DevelopmentAdverse Childhood ExperiencesAffectChild DevelopmentAdolescentChildFemaleHumansLongitudinal StudiesMaleadversityaffective disordersemotionresiliencerisk factors

Identifiers

PMID41531034
PMCPMC12952059

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.