ReviewClinical and experimental immunology2026
Circulating T-lymphocyte subsets as biomarkers for immune checkpoint inhibitors in solid tumors.
Review in Clinical and experimental immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Circulating immune cell profiling in advanced cervical and endometrial cancer patients treated with PD-1 blockade, radiotherapy, and immune modulation in the PRIMMO trial.Frontiers in immunology · 2026Trial
- Host Determinants of Immune Checkpoint Inhibitor Efficacy: Immune, Genetic, Metabolic, and Lifestyle Factors.International journal of molecular sciences · 2026Review
- Case Report: PRaG 3.0 therapy for advanced cervical cancer with severe comorbidities.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Immune Checkpoint Inhibitors (ICIs) have become a mainstay in the treatment of various solid tumors. At present, commonly used predictive biomarkers include tumor mutation burden, programed death-ligand 1 expression levels, and microsatellite instability. However, these biomarkers face inherent limitations, such as the challenges associated with tumor tissue sampling and the inability to provide dynamic monitoring. In recent years, significant efforts have been undertaken for the precise characterization of circulating T-lymphocyte subsets, with their classification offering the potential to reflect the functional state of T cells and predict responses to ICI therapy. Its advantages in terms of sampling convenience and minimally invasive nature further highlight its feasibility as a dynamic monitoring tool. This review expounds on current research progress on the use of "circulating" T-lymphocyte subsets as predictors of ICI efficacy and discusses their reliability and potential as predictive tools.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.