Evidence map›Paper›PMID 41530855›Full record

ArticleJournal of experimental & clinical cancer research : CR2026

Immunological and molecular insights into acinar-ductal metaplasia and atypical flat lesions as precursor lesions of pancreatic ductal adenocarcinoma.

Aslihan Yavas, Leon Boshoven, Kai Horny, Sebastian Haensch, Wolfgang Goering, Martin Schlensog, Lena Haeberle, Irene Esposito

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. GATA4 loss promotes mutantbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aslihan YavasInstitute of Pathology, University Hospital of Düsseldorf, Heinrich Heine University, Moorenstrasse 5, Düsseldorf, 40225, Germany.
Leon BoshovenInstitute of Pathology, University Hospital of Düsseldorf, Heinrich Heine University, Moorenstrasse 5, Düsseldorf, 40225, Germany.
Kai HornyCore Unit Bioinformatics, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Sebastian HaenschCenter for Advanced Imaging, Heinrich Heine University, Düsseldorf, Germany.
Wolfgang GoeringInstitute of Pathology, University Hospital of Düsseldorf, Heinrich Heine University, Moorenstrasse 5, Düsseldorf, 40225, Germany.
Martin SchlensogInstitute of Pathology, University Hospital of Düsseldorf, Heinrich Heine University, Moorenstrasse 5, Düsseldorf, 40225, Germany.
Lena HaeberleInstitute of Pathology, University Hospital of Düsseldorf, Heinrich Heine University, Moorenstrasse 5, Düsseldorf, 40225, Germany.
Irene EspositoInstitute of Pathology, University Hospital of Düsseldorf, Heinrich Heine University, Moorenstrasse 5, Düsseldorf, 40225, Germany. irene.esposito@med.uni-duesseldorf.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPancreatic ductal adenocarcinoma (PDAC) is known to develop through a stepwise progression from precursor lesions, such as pancreatic intraepithelial neoplasias (PanIN). An alternative carcinogenic pathway has been proposed via transformation of acinar cells, with development of acinar-ductal metaplasia (ADM) and atypical flat lesions (AFL). Defining the characteristics of PDAC precursors is crucial to better understand PDAC carcinogenesis.

methods15 KC (Ptf1a

resultsAFL showed a trend towards a more intense immune cell infiltration compared to PanIN and ADM. AFL had higher number of CD4

conclusionsOur study highlights the unique immunological and stromal features of AFL. Moreover, reinforcing their potential as precursor lesions, ADM and AFL exhibit variable alterations in the genes that have a critical role in PDAC carcinogenesis.

Indexed as

Acinar CellsCarcinoma, Pancreatic DuctalPancreatic NeoplasmsAnimalsHumansMetaplasiaMiceTumor MicroenvironmentAcinar-ductal metaplasiaAtypical flat lesionGenetic alterationsMicroenvironmentPancreatic cancer precursors

Identifiers

PMID41530855
PMCPMC12849142

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.