Evidence map›Paper›PMID 41530802›Full record

Trial reportBMC oral health2026

Effect of nanohydroxyapatite paste after different pretreatment techniques on remineralization and color change of white spot lesions in children: a randomized control study.

Maryam Mohamed El Mansy, Reham Sayed Saleh, Mohamed Farouk Rashed, Ahmed Kamal El-Motayam

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06834464 (Effect of Nanohydroxyapatite Paste After Different Pretreatment Techniques on Remineralization and Color Change of White Spot Lesions In Children), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06834464 nacompletednot on this map

Effect of Nanohydroxyapatite Paste After Different Pretreatment Techniques on Remineralization and Color Change of White Spot Lesions In Children: A Randomized Control Study.

TypeinterventionalSponsorNational Research Centre, EgyptRan2024 to 2025Enrolled40ConditionsWhite Spot LesionsArmsNanohydroxyapatite paste, HCl liquid, microabrasion
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maryam Mohamed El MansyResearcher of Pediatric Dentistry, Orthodontics and Pediatric Dentistry Department, Oral and Dental Research Institute, National Research Centre, 33 El Buhouth St, Dokki, Giza Governorate, 12622, Egypt.ORCID 0000-0002-5395-1710
Reham Sayed SalehAssociate Professor, Restorative and Dental Material Department, Oral and Dental Research Institute, National Research Centre, 33 El Buhouth St, Dokki, Giza Governorate, 12622, Egypt. rs.saleh@nrc.sci.eg.ORCID 0000-0001-5214-2797
Mohamed Farouk RashedResearcher of Pediatric Dentistry, Orthodontics and Pediatric Dentistry Department, Oral and Dental Research Institute, National Research Centre, 33 El Buhouth St, Dokki, Giza Governorate, 12622, Egypt.ORCID 0000-0003-0254-5971
Ahmed Kamal El-MotayamAssociate Professor, Department of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Cairo University, Al Saraya, Old Cairo, Cairo, 12613, Egypt.ORCID 0009-0006-5054-5545

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhite spot lesions (WSLs) are initial caries caused by early demineralization. Nanohydroxyapatite (NHA) paste is one of the most recent non-fluoridated remineralizing agents; however, few clinical studies have reported its remineralizing effect on such lesions. The aim of this study was to compare and evaluate the remineralization and color change of WSL after NHA alone was used versus NHA pretreatment with either microabrasion or sodium hypochlorite (NaOCl) and no treatment as a negative control.

methodsTwenty children aged 10 to 14 years with 40 teeth affected with WSL; were randomly assigned to 4 groups (10 teeth in each group); group I: pretreatment with microabrasion followed by NHA paste, group II: pretreatment with 5.25% NaOCl, followed by NHA paste, group III: NHA paste alone, and group IV: negative control with no treatment applied. The remineralization ability was assessed via diagnodent device and color changes were assessed via a Vita easy shade device before and after treatment; and one, two and six weeks after treatment.

resultsFor the change in Diagnodent readings, there was a significant difference between groups (I, II, III) at different intervals, which as significantly greater than that of group IV at a p value < 0.001. However, for Group IV, the change was not statistically significant (p = 0.332). The color changes measured after 2 and 6 weeks were significantly greater in groups (I), (II) and (III) than group IV (p < 0.001).

conclusionsNHA could be a good non fluoridated option to remineralize and improve the color of WSL at different treatment intervals. Pretreatment with microabrasion and NaOCl enhances its remineralization and color improvement properties.

trial registrationThis study was retrospectively registered on ClinicalTrials.gov at 6/2/2025, with ID: NCT06834464.

Indexed as

Dental CariesDurapatiteTooth RemineralizationAdolescentChildColorFemaleHumansMaleSodium HypochloriteDurapatiteSodium HypochloriteDiagnodentMicrobrasionNanohydroxyapatiteNaOClVita easy shadeWhite spots

Identifiers

PMID41530802
PMCPMC12809947

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.