Evidence map›Paper›PMID 41530792›Full record

Trial reportTrials2026

Effectiveness of maintaining oxygenation of a new high flow nasal cannula for endoscopic retrograde cholangiopancreatography during intravenous anesthesia.

Kosuke Takahashi, Eisuke Ozawa, Yasuhisa Hiroshima, Ryota Sagami, Makoto Hinokuchi, Masatoshi Murakami, Nao Fujimori, Takehiko Koga, Yusuke Ishida, Takao Ayuse and 1 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kosuke TakahashiDepartment of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan. takapochi0809@gmail.com.ORCID http://orcid.org/0000-0003-2361-5043
Eisuke OzawaDepartment of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan.
Yasuhisa HiroshimaDepartment of Gastroenterology, Faculty of Medicine, Oita University, Oita, Japan.
Ryota SagamiDepartment of Gastroenterology, Faculty of Medicine, Oita University, Oita, Japan.
Makoto HinokuchiDigestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Masatoshi MurakamiDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Nao FujimoriDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takehiko KogaDepartment of Gastroenterology and Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Yusuke IshidaDepartment of Gastroenterology and Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Takao AyuseClinical Research Center, Nagasaki, Nagasaki University Hospital, Nagasaki, Japan.
Hisamitsu MiyaakiDepartment of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1, Sakamoto, Nagasaki, 852-8501, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntravenous anesthesia during endoscopic retrograde cholangiopancreatography (ERCP) is associated with a high incidence of respiratory depression. High-flow nasal cannula (HFNC) therapy uses a mild positive pressure load to enhance carbon dioxide washout and reduce rebreathing, thereby improving respiratory function. Therefore, it is widely used to prevent hypoxemia and hypercapnia. We aim to investigate the efficacy of a new HFNC device (AIRVO 3™) in improving respiratory status during sedated ERCP.

methodsIn a multicenter randomized controlled study involving two groups-the HFNC and low-flow nasal cannula (LFNC) groups, adult patients undergo ERCP under sedation. For sedation, either the dexmedetomidine or midazolam protocol is used according to the guidelines. Pethidine hydrochloride and pentazocine are administered intravenously as analgesics. The primary endpoint is the incidence of hypoxemia, defined as peripheral oxygen saturation (SpO₂) ≤ 90% during intravenous anesthesia. As a secondary outcome, percutaneous CO DISCUSSION: This study aims to generate evidence supporting the utility of HFNC as a potential therapeutic device for ERCP under sedation by determining whether the incidence rates of hypercapnia and hypoxemia are lower in the HFNC group than in the LFNC group. TRIAL REGISTRATION {2A,2B}: The study was registered as jRCTs072240096 on January 16, 2025.

Indexed as

Anesthesia, IntravenousCholangiopancreatography, Endoscopic RetrogradeHypercapniaHypoxiaOxygen Inhalation TherapyRespiratory InsufficiencyCannulaCarbon DioxideDexmedetomidineEquipment DesignHumansHypnotics and SedativesMeperidineMidazolamOxygenOxygen SaturationCarbon DioxideDexmedetomidineHypnotics and SedativesMeperidineMidazolamOxygenPentazocineEndoscopic retrograde cholangiopancreatographyHigh-flow nasal cannulaHypoxemiaIntravenous anesthesia

Identifiers

PMID41530792
PMCPMC12888716

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.