ArticleLipids in health and disease2026
High-Density Lipoproteins (HDLs) contribute to limiting acute tissue damage: proof of concept in a model of mercury-induced nephrotoxicity.
Article in Lipids in health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPrevious studies suggest that HDLs may protect against the effects of acute injury. Given their multiple beneficial properties, this study aimed to investigate whether exogenous HDLs administration reduces acute tissue damage in a HgCl
methodsAcute tubular injury was induced in male Wistar rats with a single intraperitoneal dose of 3.5 mg/kg HgCl
resultsDuring the follow-up, plasma creatinine decreased, creatinine clearance improved, and proteinuria levels recovered more rapidly in the ATI + HDL group than in the ATI group. Glucosuria remained similar across both groups throughout the study. Histological analysis revealed increased cellularity and reduced necrosis in the kidneys of the ATI + HDL group compared to ATI rats. Rats in the ATI + Lp-B group died 48 h after HgCl
conclusionExogenous HDLs supplementation improves biochemical markers of renal function in vivo and promotes cell survival in vitro in a HgCl
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