Evidence map›Paper›PMID 41530761›Full record

ArticleVirology journal2026

Pathological characteristics of coxsackievirus A14 in neonatal mice model.

Liheng Yu, Jichen Li, Huanhuan Lu, Ying Liu, Qin Guo, Lei Zhou, Ruyi Cong, Tiantian Sun, Shuangli Zhu, Qian Yang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Liheng YuNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory of Medical Virology, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Jichen LiNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory of Medical Virology, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Huanhuan LuNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory of Medical Virology, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Ying LiuNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory of Medical Virology, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Qin GuoNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory of Medical Virology, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Lei ZhouNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory of Medical Virology, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Ruyi CongShandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 271016, China.
Tiantian SunSchool of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261053, China.
Shuangli ZhuNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory of Medical Virology, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Qian YangNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory of Medical Virology, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Tianjiao JiNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory of Medical Virology, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Yong ZhangNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory of Medical Virology, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Dongmei YanNational Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, Commission Key Laboratory for Biosecurity, National Health Commission Key Laboratory of Medical Virology, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. dongmeiyan1976@163.com.

Funding

National Key Research and Development Program of China 2024YFC2310403
6 · The paper itself

Abstract

In recent years, with the increasing incidence of other non-EV-A71 enteroviruses, the research on other enteroviruses has become more and more important. Coxsackievirus A14 (CVA14), A member of the enterovirus group A, causes hand-foot-mouth disease (HFMD), aseptic meningitis and acute abdominal pain. In this study, we established the first ICR mouse model of CVA14 infection. The CVA14 HE27 strain was selected to infect neonatal mice through a preliminary experiment, and the infection model was established according to three different conditions of infection dose, route and age. It was found that 2-day-old ICR neonatal mice showed clinical symptoms such as hind limb paralysis and death after intramuscular injection of 105.75 TCID50 CVA14 HE27 strain. Through daily monitoring, we found that the viral load of skeletal muscle was the highest, and there were certain pathological changes in various tissues and organs, among which the changes of brain and skeletal muscle were the most obvious. The expression of pro-inflammatory cytokines IL-4, IL-10, IFN-γ and TNF-α were abnormally high. This neonatal mouse model of CVA14 infection will be useful for the development of prophylactic and therapeutic multivalent vaccines, as well as for the screening of antiviral drugs against enterovirus.

Indexed as

Coxsackievirus InfectionsDisease Models, AnimalEnterovirus A, HumanAnimalsAnimals, NewbornAnimal StructuresBrainCytokinesMiceMice, Inbred ICRMuscle, SkeletalViral LoadCytokinesCoxsackievirus A14Neonatal mice modelPathogenesis

Identifiers

PMID41530761
PMCPMC12888312

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.