Evidence map›Paper›PMID 41530672›Full record

ArticleBMC microbiology2026

Population-specific dysbiosis of the salivary microbiota in Saudi adults with periodontitis.

Turki S Abujamel, Shaima M Alhazmi, Motaz Assas, Mushref B Assas, Nadine Moubayed, Munerah S BinShabaib, Shatha Subhi ALHarthi, Kawther Aabed

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Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Turki S AbujamelEcoHealth Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia. tabujamel@kau.edu.sa.
Shaima M AlhazmiEcoHealth Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Motaz AssasEcoHealth Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Mushref B AssasEcoHealth Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Nadine MoubayedDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh, 12372, Saudi Arabia.
Munerah S BinShabaibDepartment of Preventive Dental Sciences, College of Dentistry, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Shatha Subhi ALHarthiDepartment of Preventive Dental Sciences, College of Dentistry, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Kawther AabedDepartment of Biology, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo characterize the dysbiosis of salivary microbiota in Saudi adults with periodontitis and identify potential population-specific microbial signatures.

methodsSaliva samples were collected from 96 Saudi adults, including 50 patients with periodontitis and 46 control individuals. Microbiota profiling was performed using 16 S rRNA gene sequencing (V3-V4 regions), followed by QIIME2-based bioinformatics and LEfSe analysis to determine diversity and differentially abundant taxa.

resultsSignificant microbial dysbiosis was observed in the periodontitis group, characterized by higher Shannon diversity and altered community composition. A number of bacterial taxa were enriched specifically in Saudi patients with periodontitis, including Leptotrichia, Acholeplasma, and Rothia dentocariosa-taxa rarely emphasized in global studies. Other enriched taxa included Filifactor, Selenomonas, and Prevotella intermedia. In contrast, control individuals had higher levels of Streptococcus, Granulicatella, and Neisseria oralis. These patterns suggest the presence of regional microbial signatures.

conclusionsThis study reveals distinct salivary microbiota dysbiosis in Saudi adults with periodontitis and highlights unique taxa potentially linked to local environmental, dietary, or genetic factors. These findings support the need for population-specific microbial studies to inform personalized periodontal diagnostics and treatment.

Indexed as

BacteriaDysbiosisMicrobiotaPeriodontitisSalivaAdultDNA, BacterialFemaleHumansMaleMiddle AgedPhylogenyRNA, Ribosomal, 16SSaudi ArabiaSequence Analysis, DNADNA, BacterialRNA, Ribosomal, 16S16S rRNA Gene SequencingBiomarkersDysbiosisPeriodontitisSaliva microbiotaSaudi Arabian

Identifiers

PMID41530672
PMCPMC12927247

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.