Evidence map›Paper›PMID 41530601›Full record

ArticleClinical oral investigations2026

The relationship between clinical severity of obstructive sleep apnea based on polysomnography and drug-induced sleep endoscopy with 3D, 2D, linear, and angular anatomical parameters of upper airway and craniofacial area in CBCTs of individuals with moderate or severe apnea: a cross-sectional study.

Farhad Sobouti, Gholamreza Bayazian, Sunjay Suri, Benjamin Pliska, Sepideh Dadgar, Mitra Ghazizadeh Ahsaie, Atabak Nikbakht, Reza Alizadeh-Navaei, Arash Khojasteh, Mehdi Aryana and 1 more

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Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Farhad SoboutiOrthodontic Department, School of Dentistry, University of Toronto, Toronto, Canada.
Gholamreza BayazianDepartment of Otorhinolaryngology, ENT and Head & Neck Research Center, Hazrat-e Rasool General Hospital, The Five Senses Health Research Institute, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran.
Sunjay SuriThe Hospital for Sick Children, Toronto, Canada.
Benjamin PliskaDivision of Orthodontics, Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada.
Sepideh DadgarOrthodontic Department, School of Dentistry, University of Toronto, Toronto, Canada.
Mitra Ghazizadeh AhsaieDepartment of Oral and Maxillofacial Radiology, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Atabak NikbakhtENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Reza Alizadeh-NavaeiGastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Arash KhojastehDental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. arashkhojasteh@yahoo.com.
Mehdi AryanaDental Research Center, Mazandaran University of Medical Sciences, Sari, Iran. aryana_mehdi@yahoo.com.
Vahid RakhshanDepartment of Anatomy, Dental School, Azad University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study is to determine the relationship between location of upper airway respiratory collapse using drug-induced sleep endoscopy (DISE) technique and craniofacial morphology using cone beam computed tomography scans (CBCT) in patients diagnosed with moderate to severe obstructive sleep apnea (OSA).

methodsIn this prospective cross-sectional study, 64 adults with OSA (33 moderate and 31 severe) who were candidates for surgery were included. Before surgery, all patients underwent nocturnal polysomnography, DISE and CBCT scan. Measurements of craniofacial anatomical variables were performed on CBCT images. Associations among age, sex, BMI, neck circumference, CBCT measurements (3D, 2D, linear, and angular), DISE findings at various airway levels, and polysomnography indices (apnea-hypopnea index, average oxygen saturation, and minimum oxygen saturation) were analyzed using regression, ANOVA, Tukey's post-hoc test, t-test, chi-squared test, and correlation coefficients.

resultsAt the lateral wall of the velum, (1) obstructions increased AHI; (2) there were significant associations between obstructions and CBCT variables: V-RPA, V-RLA, and L-RPA (P < 0.05). Other DISE findings were mostly not associated with CBCT or polysomnography measurements, except obstructions at oropharynx-lateral which increased AHI. However, DISE-Sum was significantly correlated with AHI and oxygen saturations (P ≤ 0.009). It was also correlated with several CBCT measurements (P < 0.05); Regression analysis showed associations between DISE-Sum and Go-Me, C3H, TGL, and TGH (adjusted R

conclusionsCBCT measurements can predict OSA severity. The newly introduced DISE-Sum is highly correlated with polysomnography and CBCT findings. Individual DISE scores may be associated with AHI and CBCT only at one or two airway levels. BMI is associated with OSA. Age and neck circumference are associated with OSA only before controlling for BMI.

Indexed as

Cone-Beam Computed TomographyEndoscopyPolysomnographySleep Apnea, ObstructiveAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedProspective StudiesSeverity of Illness Index3-dimensional (3D)Apnea-hypopnea index (AHI)Average oxygen saturationCone-Beam computed tomography (CBCT)CraniofacialDrug-induced sleep endoscopy (DISE)Minimum oxygen saturationObstructive sleep apneaPolysomnography (PSG)Sex dimorphismUpper airway

Identifiers

PMID41530601

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.