Evidence map›Paper›PMID 41530582›Full record

ArticleMikrochimica acta2026

A high-throughput photothermal aptasensing platform using MnO₂@CuS nanoprobes for noninvasive detection of bladder cancer cells in simulated liquid biopsy.

Xiaohui Wu, Yiyi Zhou, Jie Chen, Han Zhang, Qingqing Zhang, Tingting Hao, Zhiyong Guo

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaohui WuState Key Laboratory for Quality and Safety of Agro-Products, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China.
Yiyi ZhouState Key Laboratory for Quality and Safety of Agro-Products, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China.
Jie ChenState Key Laboratory for Quality and Safety of Agro-Products, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China.
Han ZhangHealth Science Center, Ningbo University, Ningbo, 315211, PR China.
Qingqing ZhangState Key Laboratory for Quality and Safety of Agro-Products, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China. zhangqingqing@nbu.edu.cn.
Tingting HaoState Key Laboratory for Quality and Safety of Agro-Products, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China.
Zhiyong GuoState Key Laboratory for Quality and Safety of Agro-Products, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, PR China. guozhiyong@nbu.edu.cn.

Funding

National Natural Science Foundation of China 82273681Natural Science Foundation of Ningbo Municipality 2024J476
6 · The paper itself

Abstract

A high-throughput aptamer-based photothermal (PT) sensing platform has been developed using MnO₂@CuS nanoprobes for the noninvasive detection of exfoliated bladder cancer cells (HT-1376) in simulated liquid biopsy samples. A specific aptamer (Apt1) targeting epithelial cell adhesion molecule (EpCAM) was immobilized on an amino-functionalized glass slide to selectively capture target cells, and a thiolated aptamer-conjugated MnO₂@CuS nanoprobe (Apt2) was employed for photothermal signal output. Upon 808 nm laser irradiation, infrared thermographic imaging was used to monitor temperature elevation, enabling quantitative determination of cell concentration. The platform demonstrated a strong linear relationship between photothermal signal and HT-1376 concentration in the range 1.0 × 10 to 1.0 × 10⁶ cells/mL (R² = 0.993), with excellent sensitivity, selectivity, and repeatability. This is the first report of applying photothermal infrared imaging in a high-throughput format for tumor cell detection, offering a promising strategy for early and noninvasive diagnosis of bladder cancer via liquid biopsy.

Indexed as

Aptamers, NucleotideBiosensing TechniquesManganese CompoundsOxidesUrinary Bladder NeoplasmsCell Line, TumorEpithelial Cell Adhesion MoleculeHigh-Throughput Screening AssaysHumansLimit of DetectionLiquid BiopsyAptamers, NucleotideEpithelial Cell Adhesion MoleculeManganese CompoundsOxidesBladder cancer cellsHigh-throughput detectionLiquid biopsyMnO₂@CuSPhotothermal aptasensing platform

Identifiers

PMID41530582

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.