ArticlePediatric nephrology (Berlin, Germany)2026
N-terminal pro B-type natriuretic peptide levels in a paediatric haemodialysis cohort.
Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAccurate volume assessment is essential in the management of children on dialysis as excess volume is a key cause of arterial hypertension and is associated with the development of hypertension-mediated organ injury. Our objective was to describe NT-proBNP concentrations in a cohort of children receiving in-centre chronic intermittent haemodialysis with preserved systolic cardiac function and to evaluate relevant associations.
methodsThis was a retrospective study including prevalent children aged < 18 years who were established on IHD and had preserved systolic cardiac function.
resultsThere were 24 children, mean age 10.3 ± 5.8 years, of whom 8 had urine output < 150 mL/day, median dialysis vintage 130.3 ± 364.8 days. There were 161 post-IHD NT-proBNP measurements performed, of which 130 measurements (80.7%) were abnormal when defined as a concentration above 598 ng/L; median (IQR) 2046 (794, 5275) ng/L [Log 3.34 ± 0.58 ng/L]. Children with urine output > 150 mL/day had a mean ± SD, log NT-proBNP of 3.25 ± 0.51 ng/L and those with < 150 mL/day 3.43 ± 0.65 ng/L (P = 0.047). Following multivariable regression analysis, log NT-proBNP positively associated with systolic blood pressure z-score (SBP
conclusionsWe observed most post-haemodialysis NT-proBNP measurements to be abnormal despite preserved systolic cardiac function in children established on IHD. The utility of a single measurement remains limited and serial measurements and improved understanding of reasons for variation in intra-patient measurements may be more useful when used alongside standard clinical parameters in this population.
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