ArticleNeurology and therapy2026
Venous Blood Cell Ratios as Predictors of Reperfusion Outcomes in Ischemic Stroke: A Systematic Review and Meta-analysis.
Article in Neurology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Pre-Treatment Levels of Inflammatory Biomarkers as Predictors of Reperfusion Outcomes in Acute Ischemic Stroke: A Systematic Review and Meta-analysis.Neurology and therapy · 2026Review
- Associations of Different Inflammatory Markers with Neurological Deficit Severity and Short-Term Prognosis in Young Patients with Ischemic Stroke.Journal of inflammation research · 2026Article
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4 authors.
Funding
Abstract
introductionInflammation plays a critical role in the pathophysiology of acute ischemic stroke (AIS). Ratios derived from routine blood counts, especially the neutrophil-to-lymphocyte ratio (NLR), have been proposed as prognostic biomarkers, but their value in patients receiving reperfusion therapies-intravenous thrombolysis (IVT) or mechanical thrombectomy (MT)-remains uncertain.
methodsWe systematically searched PubMed, Cochrane Library, Web of Science, and Scopus on November 30, 2024, following PRISMA guidelines. Eligible studies included patients with AIS treated with IVT or MT that reported associations between pre-treatment blood cell ratios and outcomes measured by the modified Rankin Scale (mRS). Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects models.
resultsFifty-seven studies with 17,394 patients were included. NLR was the predominantly studied biomarker. In the MT subgroup, elevated NLR predicted poor 3-month outcome (OR 1.09, 95% CI 1.04-1.15) and higher mortality (OR 1.05, 95% CI 1.01-1.08). In IVT-treated patients, higher NLR also predicted poor outcome (OR 1.11, 95% CI 1.01-1.21) with lower heterogeneity across studies. Other ratios showed variable associations: lymphocyte-to-monocyte ratio (LMR) appeared protective, while platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-neutrophil ratio (PNR) showed inconsistent or null results. Data regarding hemorrhagic transformation were heterogeneous and unsuitable for meta-analysis.
conclusionsElevated pre-treatment NLR consistently predicted poor outcome and mortality after reperfusion therapy for AIS, supporting its role as a simple biomarker for early risk stratification. Future large, prospective multicenter studies with standardized methods are needed to confirm the clinical utility of these inflammatory ratios in stroke management.
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