ArticlePediatric research2026
Postural control in children with spastic cerebral palsy: the role of brain lesion characteristics.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostural control is often impaired in children with spastic cerebral palsy (sCP), with inter-individual differences not fully explained by CP topography or functional level. While brain lesion characteristics are known determinants of upper limb function, their predictive value for postural control remains underexplored.
methodsIn this cross-sectional study, 43 children with uni- or bilateral sCP (GMFCS I-III), aged 5-12 years, underwent standardized postural control assessment using the Kids-BESTest-2 (in percent scores). Lesion type was classified using the MRI classification scale (MRICS), and lesion extent and location were retrospectively scored on clinical MRI using the semi-quantitative MRI (sqMRI) scale. Associations between lesion characteristics and postural control domains were analyzed using stepwise regression models.
resultsChildren with predominant white or grey matter lesions performed similarly across all postural control domains. Greater lesion extent was significantly associated with poorer postural control in all domains (β = -0.8 to -1.8% per sqMRI point increase, p ≤ 0.02) except 'Sensory Orientation'. Lesions in the frontal lobe, anterior corpus callosum, PLIC, thalamus, and brainstem were the strongest predictors of domain-specific deficits, explaining up to 53% of variance.
conclusionLesion extent and location, rather than type, determine the severity and domain-specificity of postural control deficits in sCP. Lesion-specific MRI scoring may support patient-tailored rehabilitation and prognosis. IMPACT: This study demonstrates that semi-quantitative MRI-based scoring of brain lesion extent and location, rather than lesion type, is key to understanding domain-specific postural control deficits in children with spastic cerebral palsy. It provides novel evidence that damage to specific brain regions, including the frontal lobe, anterior corpus callosum, PLIC, thalamus, and brainstem, most strongly predicts impairments in distinct postural control domains. Lesion-specific MRI profiling has clinical value for identifying postural control deficits and guiding individualized rehabilitation in children with spastic cerebral palsy. Further longitudinal and multimodal research is needed to validate these findings and optimize intervention strategies.
Identifiers
41530491What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.